Is there a cure for filovirus?
The current clinical standard for filoviral infection is supportive care as there are currently no FDA-approved treatment strategies. Supportive care consists of oral fluid rehydration, oral medication, nutritional supplementation, and psychosocial support [25].
How does Filoviridae infect the body?
Fatal filovirus infections usually end with high viremia and no evidence of an immune response. In humans and monkeys, infection leads to an extensive disruption of the parafollicular regions in the spleen and lymph nodes that contain the antigen-presenting dendritic cells.
How do you get Marburg virus?
Marburg spreads through human-to-human transmission via direct contact (through broken skin or mucous membranes) with the blood, secretions, organs or other bodily fluids of infected people, and with surfaces and materials (e.g. bedding, clothing) contaminated with these fluids.
How are Filoviruses transmitted?
Filoviruses are believed to be transmitted from wildlife to people through contact with reservoir fruit bats, and through intermediate or amplifying hosts, such as monkeys, great apes, duikers or pigs that have themselves become infected through contact with bat saliva or feces [23,31].
How do Filoviruses replicate?
Filovirus replication and transcription take place in the cytoplasm of the infected cells. The viruses encode their own RNA-dependent RNA polymerase, which recognizes the encapsidated negative-strand RNA genome as a template for replication and transcription.
What are the 3 Filoviruses?
First discovered in 1967, the filovirus refers to any virus that belongs to the Filoviridae family of viruses that sit within the Mononegavirales order. Three genera are included within the family: Cuevavirus, Ebolavirus, and Marburgvirus.
What are the symptoms of multiple sclerosis ( MS )?
Multiple sclerosis. Multiple sclerosis. In multiple sclerosis, the protective coating on nerve fibers (myelin) is damaged and may eventually be destroyed. Depending on where the nerve damage occurs, MS can affect vision, sensation, coordination, movement, and bladder and bowel control. Multiple sclerosis (MS) is a potentially disabling disease
What are the symptoms of a filovirus infection?
Symptoms: Back pain, nausea, vomiting, chest pain, a sore throat, abdominal pain, and diarrhea first appear. Symptoms become increasingly severe and can include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, massive hemorrhaging, and multi-organ dysfunction.
How does the Filo virus cause hemorrhagic fever?
Filo viruses were first discovered in 1967 as the main cause for several diseases that are known to cause hemorrhagic fever; or massive loss of blood internally and externally. All filoviruses are spread through body fluid and intimate contact.
Is there any effective treatment for a filovirus?
Because there is no known effective treatment for the hemorrhagic fevers caused by Filoviruses, transmission prevention through application of viral hemorrhagic fever isolation precautions is currently the centerpiece of Filovirus control.