Is CXCL2 a proinflammatory?
CXCL2 is a chemoattractant chemokine with proinflammatory function and its downregulation could reduce the recruitment of polymorphonuclear cells, which are key players in the clearing of L. monocytogenes during infection.
What cells express CXCL2?
CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.
What is the receptor for CXCL2?
CXCR2 is the putative receptor that is known to mediate CXCL2 and CXCL3 function.