Is cisapride safe for humans?
Potentially life-threatening side effects include QT prolongation and ventricular arrhythmias, the primary concern in humans that led to cisapride’s removal from the market in the United States. In cats QT prolongation associated with cisapride administration requires 20 times the therapeutic dose.
Why is cisapride banned?
Janssen Pharmaceutica, in consultation with the FDA, has decided to stop marketing the prokinetic agent cisapride (Propulsid®) on July 14, 2000 due to the risk of serious cardiac arrhythmias and death associated with this agent.
How does cisapride cause arrhythmia?
Cisapride (Prepulsid™) causes QT-prolongation which may worsen to life-threatening torsade de pointes. The WHO database holds 159 reports of these events. Many patients were taking interacting medicines, most commonly erythromycin, fluconazole, clarithromycin and amiodarone.
How does cisapride work in the body?
Cisapride has been used widely to treat gastric-emptying disorders, intestinal transit and other motility disorders in both dogs and cats. It accelerates emptying the stomach and propulsion of food through the intestines by increasing peristalsis.
How long does cisapride stay in your system?
This short-acting medication should stop working within 24 hours, although effects can be longer in pets with liver or kidney disease.
What is cisapride taken for?
CISAPRIDE (SIS a pride) is used to treat heartburn in patients with gastroesophageal reflux disease (GERD). Because of the serious risks associated with this medicine it should only be used when lifestyle changes and other medicines have not worked.
What is cisapride for humans?
Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments.
What kind of drug is cisapride?
Cisapride (brand names: Prepulsid®, Propulsid®) is a medication used to enhance the movement of the gastrointestinal (GI) system to treat conditions such as stasis, reflux, and constipation/megacolon (in cats).
What is cisapride used for?
What is cisapride used for in humans?
What can be used instead of cisapride?
Many currently available medications have equivalent or greater efficacy than cisapride for indications such as gastro-oesophageal reflux disease, functional dyspepsia, oesophageal dysmotility and constipation. The alternatives include acid suppressing drugs, domperidone, metoclopramide and laxatives.
When to call the doctor about cisapride side effects?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using cisapride and call your doctor at once if you have a serious side effect such as: feeling like you might pass out. Less serious side effects may include: increased urination.
Can you take cisapride with or without food?
Cisapride may be given with or without food. If a dose is accidentally skipped, do not double up on the next dose. Because of its effect on smooth muscle contraction, cisapride can also be used in urinary retention situations to strengthen bladder contraction.
What happens if you take cisapride without syncope?
QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. Most patients had disorders that may have predisposed them to arrhythmias with cisapride.
How many milligrams of Cisapride is in Propulsid?
Each 1.04 mg of cisapride as the monohydrate is equivalent to one mg of cisapride. Propulsid (cisapride removed from us market) is available for oral use in tablets containing cisapride as the monohydrate equivalent to 10 mg or 20 mg of cisapride and as a suspension containing the equivalent of 1 mg/ml of cisapride.