Which pathophysiologic mechanism is associated with multiple sclerosis?
The mechanism of demyelination in multiple sclerosis may be activation of myelin-reactive T cells in the periphery, which then express adhesion molecules, allowing their entry through the blood-brain barrier (BBB).
How can you tell the difference between multiple sclerosis and transverse myelitis?
In transverse myelitis there is usually a single lesion in the spinal cord and none in the brain, whereas in multiple sclerosis (MS) there are multiple attacks of inflammation and lesions throughout the brain and spinal cord.
Is transverse myelitis related to MS?
Transverse myelitis can appear as the first symptom in conditions such as multiple sclerosis (MS) or neuromyelitis optica (NMO). A person with transverse myelitis who also has an abnormal brain MRI with more than two lesions has an increased chance (as high as 90 percent) of going on to develop MS.
What does MS do to myelin?
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. In this disorder, your immune system attacks the myelin sheath or the cells that produce and maintain it. This causes inflammation and injury to the sheath and ultimately to the nerve fibers that it surrounds.
What do scientists hypothesized to be the causes of MS?
The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease in which the body’s immune system attacks its own tissues. In the case of MS , this immune system malfunction destroys the fatty substance that coats and protects nerve fibers in the brain and spinal cord (myelin).
Does MS cause legs to feel heavy?
The muscle weakness that you are feeling can be directly linked to MS because the damage to your nerves can disrupt signals to the muscles. This nerve damage makes it hard to move your muscles and leads to a heavy feeling in your legs (or other areas of your body).
What does MS spasticity feel like?
It is one of the more common symptoms of MS. Spasticity may be as mild as the feeling of tightness of muscles or may be so severe as to produce painful, uncontrollable spasms of extremities, usually of the legs. Spasticity may also produce feelings of pain or tightness in and around joints, and can cause low back pain.
What are some symptoms associated with multiple sclerosis that might explain the importance of the myelin sheath?
In multiple sclerosis, the protective coating on nerve fibers (myelin) in the central nervous system is damaged. This creates a lesion that, depending on the location in the central nervous system, may cause symptoms such as numbness, pain or tingling in parts of the body.