Which drugs are prokinetic?
Types of Prokinetics
- Bethanechol. Bethanechol (Urecholine) is a medication that stimulates the bladder and helps you pass urine if you are having trouble emptying your bladder.
- Cisapride. Cisapride (Propulsid) acts on serotonin receptors in the stomach.
- Metoclopramide.
What are some examples of Prokinetics?
Examples
- Benzamide.
- Cisapride.
- Domperidone.
- Itopride.
- Mosapride.
- Metoclopramide.
- Prucalopride.
- Renzapride.
Which is the best prokinetic drug?
Erythromycin. Erythromycin is the most potent prokinetic drug when given intravenously in the acute setting and is therefore useful in the initial management of hospitalized patients with severe gastroparesis.
What are examples of Promotility drugs?
The most widely studied agents include bethanechol, metoclopramide, domperidone and cisapride. These drugs act either by enhancing the effect of acetylcholine or by blocking the effect of an inhibitory neurotransmitter such as dopamine.
Is azithromycin a prokinetic?
Azithromycin is assumed to have prokinetic characteristics (improved gastric emptying) similar to those of erythromycin.
Is domperidone a prokinetic?
Domperidone is another prokinetic that can be considered and is commonly used in the outpatient setting to treat gastroparesis. However, domperidone is associated with risk of QT interval prolongation [23].
Is omeprazole a prokinetic?
A variety of pharmacologic agents are available for suppressing gastric acid secretion. These include H2RAs such as famotidine, nizatidine, and cimetidine; proton pump inhibitors (PPIs) such as omeprazole; prokinetic agents such as cisapride and tegaserod; and mucosal cytoprotectants such as sucralfate.
What is a natural prokinetic?
Natural prokinetic agents include ginger, herbal bitters (eg, gentian root, dandelion root and leaf, burdock root), and a formulation called Iberogast.
Is omeprazole a prokinetic agent?
What are prokinetic drugs used for?
Prokinetic agents, such as metoclopramide (Reglan), improve the motility of the esophagus and stomach and increase the lower esophageal sphincter (LES) pressure to help reduce reflux of gastric contents. They also accelerate gastric emptying.
Is sucralfate a prokinetic?
If a prokinetic drug is used, tegaserod (Zelnorm) is the drug of choice because it decreases reflux and esophageal sphincter relaxation. Sucralfate (Carafate) may be used as an adjunct treatment to protect injured mucosa.
Are there any prokinetic drugs that can be prescribed?
Researchers continue to look at ways to improve prokinetics so they cause fewer side effects. Prokinetics are available in tablet, oral solution and injection form. Certain prokinetics such as cisapride and domperidone are not available by prescription in the United States.
What are the functions of the prokinetic agents?
One of the functions of the PNS is controlling your digestion. The prokinetic agents in this class include bethanechol, which was used to treat heartburn and gastroparesis, a condition that causes partial paralysis in your stomach. Bethanechol is not often used for this anymore because of its side effects.
Are there any side effects to taking prokinetics?
Prokinetics have been linked to several significant side effects, some of which are potentially fatal. For example, cisapride has been associated with fatal heart arrhythmias (abnormalities in heartbeat rhythm). For this reason, this drug is not prescribed in the United States.
Are there any macrolide antibiotics that are prokinetic?
Other macrolide antibiotics have prokinetic activity with fewer adverse effects than erythromycin and may be suitable for use in small animals. Both erythromycin and clarithromycin are metabolized by the hepatic cytochrome P450 enzyme system and inhibit the hepatic metabolism of other drugs, including theophylline, cyclosporine, and cisapride.