What is toluenesulfonic acid used for?
p-toluene sulfonic acid is widely used as catalyst agent in the synthesis of pharmaceuticals, pesticides, polymerization stabilizer and organic synthesis (esters, etc.), paint intermediates and resin curing agent. And it is also the commonly used acid catalyst in organic synthesis.
Is p-Toluenesulfonic acid soluble in water?
p-Toluenesulfonic acid is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). p-Toluenesulfonic acid (PTSA or pTsOH) or tosylic acid (TsOH) is an organic compound with the formula CH3C6H4SO3H. It is a white solid that is soluble in water, alcohols, and other polar organic solvents.
How do you dry p-Toluenesulfonic acid?
p-Toluenesulfonic acid monohydrate was dried at 80 °C under high-vacuum for 48 h. Dry THF, toluene and CH2Cl2 were obtained by using a solvent drying system from Innovative Technologies.
Is toluenesulfonic acid a strong acid?
As with other aryl sulfonic acids, TsOH is a strong organic acid.
Is P toluenesulfonic acid corrosive?
* p-Toluene Sulfonic Acid is a CORROSIVE CHEMICAL and contact can cause severe skin and eye irritation and burns.
How does sulfonation occur?
Sulfonation is a reversible reaction that produces benzenesulfonic acid by adding sulfur trioxide and fuming sulfuric acid. The reaction is reversed by adding hot aqueous acid to benzenesulfonic acid to produce benzene.
Why is Psoso catalyst?
The ability to recover and reuse the catalyst from the reaction mixtures, minimal generation of environmentally unfriendly waste, high specificity of the reaction, and the low cost are important advantages of the TsOH catalyst over the other conventional Friedel−Crafts catalysts.
What is the structure of p toluene?
p-Toluenesulfonic acid
| PubChem CID | 6101 |
|---|---|
| Structure | Find Similar Structures |
| Chemical Safety | Laboratory Chemical Safety Summary (LCSS) Datasheet |
| Molecular Formula | C7H7SO3H or C7H8O3S or CH3C6H4SO3H |
| Synonyms | P-TOLUENESULFONIC ACID 4-Methylbenzenesulfonic acid 104-15-4 4-Toluenesulfonic acid p-Toluenesulphonic acid More… |
Why is sulfonic acid so acidic?
The hydrogen atom makes the compound acidic, much as the hydrogen of a carboxylic acid (see carboxyl group) makes it acidic (see acids and bases). Because sulfonic acids are so acidic, they generally exist as their salts and thus tend to be quite soluble in water.
Is acetic acid hazardous?
Effects on Humans: In vapor form, acetic acid is a severe irritant of the eyes, mucous membranes, upper respiratory tract, and skin. In contact with the skin or eyes, acetic acid solutions of 80% or more can be corrosive, causing severe burns of any exposed tissue.
What kind of acid is p-toluenesulfonic acid?
HPLC Separation of Benzenesulfonic and p-Toluenesulfonic Acids. Benzenesulfonic and toluenesulfonic acids are organic acids used in pharmaceutical industry as counter-ions for basic drugs. Both acids are hydrophilic in nature with strong acidic properties.
How is HPLC used for drug quantitation?
This HPLC method can be used for simultaneous quantitation of other basic drugs and counter-ions. The presence of two mechanisms of retention allows control over retention times of drug and counter-ion independently, and even allows a change of order of elution when necessary.
Can a HPLC method be used to detect ELSD?
The detection technique depends on the properties of the counter-ions. In case of low or no UV activity, ELSD can be employed if the counter-ion forms a non-volatile salt with the mobile phase additive (ammonium formate). This HPLC method can be used for simultaneous quantitation of other basic drugs and counter-ions.
Which is the best HPLC column for ionic liquids?
An effective and universal method for analysis of ionic liquids is developed on an Obelisc R HPLC column. Components on the ionic liquids are retained based on ionic and hydrophobic interactions.