What is the prototype for raloxifene?
Raloxifene, the prototype of the selective estrogen receptor modulators, has been associated with an increased risk of venous thromboembolism.
What is raloxifene HCL used for?
Raloxifene is used to prevent and treat osteoporosis (condition in which the bones become thin and weak and break easily) in postmenopausal (women who have experienced a change of life; end of menstrual periods) women.
What is the mechanism of action of raloxifene?
The mechanism of action of raloxifene occurs through binding to estrogen receptors. This binding results in activation of estrogenic pathways (estrogen-agonistic effect) and blockade (estrogen-antagonistic effect) in tissues that express estrogen receptors.
How is raloxifene metabolized?
Metabolism. Raloxifene is metabolized in the liver and undergoes enterohepatic recycling. It is metabolized exclusively by glucuronidation and is not metabolized by the cytochrome P450 system. Less than 1% of radiolabeled material in plasma comprises unconjugated raloxifene.
What time of day should I take raloxifene?
You can take raloxifene at whatever time of day you find easiest to remember but try to take your doses at the same time of day, each day. This will help you to remember to take your doses regularly. You can take the tablet either before or after a meal. If you forget to take a dose, take it as soon as you remember.
How long is it safe to take raloxifene?
Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment (treatment >3 years).
What are the benefits of raloxifene?
Raloxifene is used by women to prevent and treat bone loss (osteoporosis) after menopause. It slows down bone loss and helps to keep bones strong, making them less likely to break. Raloxifene may also lower the chance of getting a certain type of breast cancer (invasive breast cancer) after menopause.
Is raloxifene safe to take?
The incidence of cataracts in the raloxifene group is similar to that seen for the general population. The prevalence of low BMD and osteoporosis increases with greater severity of chronic kidney disease, and raloxifene is safe and effective for postmenopausal women affected by chronic kidney disease.
How long should raloxifene be taken?
Do you need a prescription for raloxifene?
Raloxifene is a prescription drug used by women to prevent and treat bone loss (osteoporosis) after menopause.
Is raloxifene liver toxic?
Serum enzyme elevations are uncommon during raloxifene therapy and are rarely dose limiting. While clinically apparent liver injury with jaundice has been reported with raloxifene therapy, it is very rare.
How long can you stay on raloxifene?
What is the molecular formula for raloxifene hydrochloride?
Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4S•HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl, USP is an off-white to pale-yellow solid that is very slightly soluble in water. Raloxifene hydrochloride tablets, USP are supplied in a tablet dosage form for oral administration.
How does Raloxifene hydrochloride work in breast cancer?
In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer.
Who is at risk for taking raloxifene hydrochloride tablets?
Increased risk of deep vein thrombosis and pulmonary embolism have been reported with raloxifene hydrochloride tablets ( 5.1 ). Women with active or past history of venous thromboembolism should not take raloxifene hydrochloride tablets ( 4.1 ).
What are the effects of raloxifene on osteoporosis?
Raloxifene Hydrochloride is the hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast,…