What is the meaning of hexokinase?
Definition of hexokinase : any of a group of enzymes that accelerate the phosphorylation of hexoses (as in the formation of glucose-6-phosphate from glucose and ATP) in carbohydrate metabolism.
Is hexokinase positive or negative?
Hexokinase IV (“glucokinase”) Hexokinase IV is monomeric, about 50kD, displays positive cooperativity with glucose, and is not allosterically inhibited by its product, glucose-6-phosphate.
What is the EC number of hexokinase?
IntEnz – EC 2.7. 1.1.
How is hexokinase 1 regulated?
Hexokinases I–III are inhibited by glucose 6-phosphate in a noncompetitive manner with respect to glucose, but competitive versus ATP. Inhibition by glucose 6-phosphate takes place at physiological concentrations, which argues for its physiological significance.
What happens if hexokinase is high?
In most cells a hexokinase with a high affinity for glucose—i.e., only small amounts of glucose are necessary for enzymatic activity—effects the reaction. In addition, the liver contains a glucokinase, which requires a much greater concentration of glucose before it reacts.
Where is hexokinase found in the body?
Glucokinase (hexokinase D) is a monomeric cytoplasmic enzyme found in the liver and pancreas that serves to regulate glucose levels in these organs.
What type of enzyme is Phosphoglucoisomerase?
Phosphoglucoisomerase (alternatively known as phosphoglucose isomerase or Glucose-6-phosphate isomerase) are a group of enzymes of the isomerase family (EC 5.3. 1.9), so named for their main function in glycolysis and gluconeogenesis. See Glycolysis Enzymes.
What is the cofactor for hexokinase?
The enzyme hexokinase requires a magnesium ion as a cofactor.
What does hexokinase 2 do?
Hexokinase II phosphorylates glucose to regulate glucose metabolism but also functions as a protective signaling molecule. Hexokinase II is the predominant isoform in insulin-sensitive tissues and upregulated in tumors. Hexokinase II binds and inhibits TORC1 to facilitate autophagy in response to glucose deprivation.
What does hexokinase 1 do?
Function. As one of two mitochondrial isoforms of hexokinase and a member of the sugar kinase family, HK1 catalyzes the rate-limiting and first obligatory step of glucose metabolism, which is the ATP-dependent phosphorylation of glucose to G6P.
Is hexokinase 1 found in liver?
What is high hexokinase?