What is the main complication of Kawasaki disease?
Aneurysms of the coronary arteries, the blood vessels that supply oxygen to the heart itself, are the most important complication of Kawasaki disease. With appropriate and timely treatment, the risk of coronary artery involvement decreases to around 5 percent.
Can chemicals cause Kawasaki disease?
Kawasaki Disease Causes and Risk Factors It might be linked to genes, viruses, bacteria, and other things in the world around a child, such as chemicals and irritants.
What labs are elevated with Kawasaki disease?
As for laboratory findings in KD, many inflammatory indices change throughout the disease process; elevated levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), leukocyte count with neutrophilia (lymphopenia), platelet count, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and …
What type of vasculitis is Kawasaki disease?
Kawasaki disease arteritis and polyarteritis nodosa belong to the medium-sized vessel vasculitis category. There is no problem distinguishing acute Kawasaki disease arteritis from the two major large vessel vasculitides (Takayasu arteritis and giant cell arteritis).
Can Kawasaki cause heart failure?
The heart-related complications associated with Kawasaki disease are serious and may be fatal in 2 to 3% of cases that go untreated. Children under the age of 1 are known to be at higher risk of serious complications.
Is Kawasaki hard to diagnose?
There is no specific test for Kawasaki disease. One challenge in diagnosing Kawasaki disease is distinguishing it from other childhood diseases with similar symptoms. To be diagnosed with classic Kawasaki disease, a child must have a high fever for at least five days, as well as four of the five classic symptoms.
What labs indicate Kawasaki?
A typical initial laboratory evaluation may include a complete blood count (CBC), electrolyte panel, renal function testing, liver enzymes, albumin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and urinalysis.
What is the first line treatment of Kawasaki disease?
First-line treatment for Kawasaki disease is IVIG in a dose of 2 g per kg of body weight in a single infusion. For treatment of Kawasaki disease, high-dose aspirin (80 to 100 mg per kg per day, divided into four doses) should be given with IVIG.
When should I take aspirin for Kawasaki disease?
Once the patient has remained afebrile for 48-72 hours, low-dose aspirin is often initiated for its antiplatelet activity. The dose is 3-5 mg/kg/day for a total of 6-8 weeks as long as the patient shows no evidence of coronary abnormalities.