What is factor V Leiden?
Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.
What blood type is factor V Leiden?
The O blood group protects against venous thromboembolism in individuals with the factor V Leiden but not the prothrombin (factor II G20210A) mutation. Blood Coagul Fibrinolysis.
Is factor V Leiden dominant or recessive?
Genetic counseling: Factor V Leiden thrombophilia (i.e., predisposition to the development of venous thrombosis) is inherited in an autosomal dominant manner. Homozygosity for the Leiden variant (and a much greater risk for venous thrombosis) are inherited in an autosomal recessive manner.
What is Factor 5 called?
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor.
Are there different types of Factor V Leiden?
Some people do not have the normal Factor V protein. Instead, they have an different form called Factor V Leiden. This is caused by a change (mutation) in the gene for this protein. The different gene that makes the Factor V Leiden protein is inherited from one or both parents.
Can you have a baby if you have factor V Leiden?
Factor V Leiden can also increase the risk of miscarriage and complications of pregnancy such as stillbirth and the blood clots in the placenta and umbilical cord. Despite these risks, most people with factor V Leiden never develop abnormal clots, and most women with factor V Leiden have normal pregnancies.
Does aspirin help factor V Leiden?
Though factor V Leiden alone does not seem to raise the risk of arterial clots, something as simple as daily therapy with low-dose aspirin may help prevent a heart attack or stroke in people with factor V Leiden if they have additional risk factors.
Do blood clots run in families?
Pulmonary embolism can run in families, if there is a family history of blood clots or other vein disorders, heart disease, or lung conditions. For example, deep vein thrombosis (DVT), in which a blood clot forms in the deep veins of the legs or arms, has been known to run in families.
Does factor V Leiden affect pregnancy?
Factor V Leiden is the most common cause of primary and recurrent venous thromboembolism in pregnancy. Factor V Leiden carriage has consistently been shown to increase the risk of early onset gestational hypertension and HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) in pregnancy.
What is the function of Factor 5?
Factor 5 (F5) Gene Mutations Factor V (FV) is a procoagulant molecule that interacts with other clotting proteins including activated factor X and PT to increase the production of thrombin, the key hemostatic enzyme that converts soluble fibrinogen to a fibrin clot [3].
What do you need to know about factor V Leiden?
Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.
Why are blood clots more common with Factor V Leiden thrombophilia?
However, in people with factor V Leiden thrombophilia, coagulation factor V cannot be inactivated normally by APC. As a result, the clotting process remains active longer than usual, increasing the chance of developing abnormal blood clots. Other factors also increase the risk of developing blood clots in people with factor V Leiden thrombophilia.
What is the medical definition of factor V?
factor V Lei·den | \\-ˈlī-dᵊn \\. 1 : a point mutation producing an abnormal version of factor V that is resistant to inactivation and causes prolonged clotting of blood.
Is the blood disorder Factor V Leiden contagious?
Factor V Leiden. Factor V Leiden (five LY dehn) is an inherited blood disorder. It is not contagious (it cannot be passed through person-to-person contact). It is genetic (in the genes). Genes are tiny parts of cells that tell the cells how to grow. We inherit a set of genes from each parent.