What is Beractant and Poractant?
Beractant is an extract from bovine lungs and contains 25 mg/mL phospholipids, whereas poractant alfa is an extract from porcine lungs and contains 74–76 mg/mL phospholipids; both preparations contain smaller concentrations of natural surfactant-associated proteins and are suspended in 0.9% saline solution [5,6,7,8].
What is CUROSURF used for?
Curosurf is used to treat or prevent Respiratory Distress Syndrome (RDS) in newborn babies. Most babies are born with a substance in their lungs known as ‘surfactant’.
How much does CUROSURF cost?
The cost for Curosurf intratracheal suspension (80 mg/mL) is around $525 for a supply of 1.5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How is CUROSURF administered?
Administer CUROSURF suspension through the proximal end of the secondary lumen of the endotracheal tube as a single dose, given over 1 minute, and without interrupting mechanical ventilation.
Can CUROSURF cause a pulmonary hemorrhage?
Pulmonary hemorrhage, a known complication of premature birth and very low birth-weight, has been reported both in clinical trials with CUROSURF and in postmarketing adverse event reports in infants who had received CUROSURF.
What is CUROSURF made from?
CUROSURF is a natural surfactant, prepared from porcine lungs, containing almost exclusively polar lipids, in particular phosphatidylcholine (about 70% of the total phospholipid content), and about 1% of specific low molecular weight hydrophobic proteins SP-B and SP-C.
When do you administer CUROSURF?
The initial recommended dose of CUROSURF is 2.5 mL/kg birth weight. Up to 2 repeat doses of 1.25 mL/kg birth weight each may be administered at approximately 12‑hour intervals. A total of 4 doses of Survanta (4 mL/kg birth weight) can be administered no more frequently than every 6 hours in the first 48 hours of life.
How fast does CUROSURF work?
CUROSURF improves oxygenation within 5 minutes and rapidly reduces FiO2 requirements over the initial treatment period—delivering better short-term efficacy. Physiological end points (eg, faster reduction in FiO2) have not been proven to impact key clinical outcomes such as mortality due to RDS.
What is CUROSURF made of?
When was CUROSURF invented?
In the 1980s Bengt Robertson and Tore Curstedt developed a porcine surfactant, Curosurf (named after their surnames), which was effective in immature animals and was used in a pilot clinical trial beginning in 1983.
How long is CUROSURF good for?
Pull the plastic cap with the aluminum portion downwards. Remove the whole ring by pulling off the aluminum wrapper. Remove the rubber cap to extract content. Unopened, unused vials of CUROSURF suspension that have warmed to room temperature can be returned to refrigerated storage within 24 hours for future use.
Who invented curosurf?