What does a positive antiphospholipid antibody mean?
High levels of this antibody may mean you have a higher risk for blood clots. Your healthcare provider can’t predict when a clot may happen. You may need a second test in about 12 weeks to confirm the results. A positive result doesn’t mean you need treatment.
What causes high beta-2 glycoprotein?
Beta-2 GP1 antibodies are found with increased frequency in patients with systemic rheumatic diseases, especially systemic lupus erythematosus. Beta-2 GP1 antibodies are detected in the clinical laboratory by different types of assays including immunoassays and functional coagulation assays.
What is a normal range for beta-2 glycoprotein?
Normal: β2 GPI IgG ≤ 20 SGU U/mL. β2 GPI IgM ≤ 20 SMU U/mL.
What is anti b2gpi antibody test?
Beta 2GP1 Ab. Beta-2 glycoprotein 1 antibodies (IgG, IgM, and very rarely IgA) 28 February 2018. This article waslast modified on 5 August 2021. To help investigate inappropriate blood clot formation; to help determine the cause of recurrent miscarriage; as part of an evaluation for antiphospholipid syndrome (APS)
What does high glycoprotein mean?
A high level of beta-2 glycoprotein 1 antibody that is tested and confirmed as positive 12 weeks later means that it is likely that you have APS. This is especially true if other antiphospholipid antibody tests are positive.
What does a positive beta-2 glycoprotein mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What does b2 glycoprotein do?
Functional roles of β2GPI. The two main functions of β2GPI to regulate complement and coagulation are relevant to the pathogenesis of APS. The ability of β2GPI to regulate coagulation is complex since it has antithrombotic (both anticoagulant and antiplatelet) as well as procoagulant effects.
What is anti b2 glycoprotein?
Anti-beta-2-glycoproteins (anti-B2GP1 antibodies, anti-beta-2-glycoprotein antibodies) are antibodies produced by an individual’s immune system against his or her own phospholipids. These phospholipids are found on the surface of the platelets responsible for blood clotting (clot formation).
How do you test for antiphospholipid antibodies?
To test for APS antibodies, a small blood sample is taken. It’s often drawn from a vein in your arm using a needle. The procedure usually is quick and easy, but it may cause some short-term discomfort and a slight bruise. You may need a second blood test to confirm positive results.
What is anti glycoprotein?
What are beta-2 glycoprotein 1 antibodies for APS?
Strongly positive results for IgG and IgM beta-2 glycoprotein 1 (beta-2 GP1) antibodies (>40 U/mL for IgG and/or IgM) are diagnostic criterion for antiphospholipid syndrome (APS). Lesser levels of beta-2 GP1 antibodies and antibodies of the IgA isotype may occur in patients with clinical signs of APS, but the results are not considered diagnostic.
What should you know about anti β 2 GPI antibodies?
Given all these uncertainties, one should be careful to interpret the results of an anti-β 2 GPI antibody ELISA. A combination of a positive anti-β 2 GPI antibody ELISA and a positive LA will identify patients at risk, whereas patients with a single positivity of anti-β 2 GPI antibodies should be considered at low risk for adverse clinical events.
Can a beta 2 GP1 antibody be detected by an anticoagulant?
Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment. The immunoassay for beta-2 glycoprotein 1 (beta 2 GP1) antibodies does not distinguish between autoantibodies and antibodies produced in response to infectious agents or as epiphenomena following thrombosis.
What is the reference value for beta-2 glycoprotein 1?
Results are expressed in arbitrary units. Reference values apply to all ages. Strongly positive results for IgG and IgM beta-2 glycoprotein 1 (beta-2 GP1) antibodies (>40 U/mL for IgG and/or IgM) are diagnostic criterion for antiphospholipid syndrome (APS).