What does a high interleukin 13 mean?
IL-13 levels are elevated in animal models of eosinophilic inflammation and in the blood and tissue of patients diagnosed with eosinophilic disorders. IL-13 signaling elicits many pathogenic mechanisms including the promotion of eosinophil survival, activation, and trafficking.
What is the role of interleukin 13?
IL-13 can activate monocyte cell lines and inhibit the production of inflammatory cytokines (IL-1α, IL-1β, IL-6, IL-8, G-CSF, and IFN-α), for example, from macrophages activated with LPS. IL-13 causes the Ig isotype switch in B lymphocytes into IgE, and thus has a role in development of allergies.
Is IL-13 anti inflammatory?
From these observations, it can be concluded that IL-13 is an antiinflammatory cytokine that plays a unique role in the induction and maintenance of IgE production and IgE-mediated allergic responses.
What is type2 asthma?
Type 2 asthma is characterised by Type 2 inflammation and typically includes allergic asthma, exercise-induced asthma, and late-onset eosinophilic asthma. Understanding of allergic, eosinophilic, and mixed allergic/eosinophilic phenotypes has greatly advanced and may underpin new approaches to improve asthma control.
Is IL-13 inflammatory?
Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation. IL-13 is involved in Th2 inflammation and has been identified as a possible therapeutic target in the treatment of asthma.
Is IL-13 a protein?
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31 with a length of 1.4kb. IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes.
What are the side effects of interleukin 13?
IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia, and glycoprotein hypersecretion, which all contribute to airway obstruction ( Figure 2 ).
Where is the gene for interleukin 13 located?
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31 with a length of 1.4kb.
Which is co induced with interleukin 13 ( IL-13 )?
MAO-A expression is co-induced with 15-lipoxygenase (15-LO) in interleukin 13 (IL-13)-activated primary human monocytes and A549 non-small cell lung carcinoma cells.
What are the effects of IL-13 on immune cells?
Functions. IL-13 has effects on immune cells that are similar to those of the closely related cytokine IL-4. However, IL-13 is suspected to be central mediator of the physiologic changes induced by allergic inflammation in many tissues. Although IL-13 is associated primarily with the induction of airway disease,…