What can cause elevated alkaline phosphatase levels?
The most common causes of high ALP levels include:
- liver conditions, often bile duct obstructions.
- gallbladder conditions, usually gallstones.
- bone conditions, such as abnormal growths and occasionally cancers.
- pregnancy.
- young age, as children who are still growing tend to have much higher ALP levels.
What is considered moderately high levels of alkaline phosphatase?
The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Children and pregnant women can have significantly higher levels of the enzyme in their blood [1]. Values above 130 U/L are usually considered to be high.
What medications can cause elevated alkaline phosphatase?
Some examples of drugs that may cause a raised alkaline phosphatase include:
- Antibiotics: penicillin derivatives (1)
- Antiepileptic drugs: Carbamazepine.
- Antihistamines: Cetirizine (1)
- Cardiovascular drugs: Captopril (1)
- Disease modifying agents:
- Polycyclic aromatic hydrocarbons:
- Psychotropic drugs:
- Diabetes drugs:
What causes fever and elevated liver enzymes?
More common causes of elevated liver enzymes include: Over-the-counter pain medications, particularly acetaminophen (Tylenol, others) Certain prescription medications, including statin drugs used to control cholesterol. Drinking alcohol.
What does alkaline phosphatase indicate?
Moderately high levels of alkaline phosphatase may indicate conditions such as Hodgkin lymphoma, heart failure, or a bacterial infection. Low levels of alkaline phosphatase may indicate hypophosphatasia, a rare genetic disease that affects bones and teeth.
Does fasting affect alkaline phosphatase?
Alkaline phosphatase activity was decreased at 8 hours of fasting, with further declines in activity of the serum enzyme seen at 16, 24, and 48 hours of fasting.
Can vitamin D increase alkaline phosphatase?
The correlation coefficient of alkaline phosphatase and serum vitamin D3 levels was r =0.05 (p =0.593). Conclusion: Serum vitamin D3 levels may not be correlated with increased serum alkaline phosphatase levels. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency.