Is DMF a strong base?
In pubchem, i found the pKa of DMF is -0.3. However it is a strong base, which means its pKa value should be high (>16).
Where is DMF used?
DMF is used in the production of acrylic fibers and plastics. It is also used as a solvent in peptide coupling for pharmaceuticals, in the development and production of pesticides, and in the manufacture of adhesives, synthetic leathers, fibers, films, and surface coatings.
Is DMF harmful?
DMF is readily absorbed through the skin, inhaled, or ingested. DMF is a potent liver toxin. DMF may cause abdominal pain, constipation, nausea and vomiting, headache, weakness, dizziness, skin problems, and alcohol intolerance. Current evidence associating DMF with cancer in humans is not conclusive.
Is DMF UV active?
UV Cutoff of N,N-Dimethylformamide is 268 nm according to literature.
Is DMF a VOC?
It is a volatile organic compound and a member of formamides. It derives from a formamide. Dimethylformamide is used as an industrial solvent and in the production of fibers, films, and surface coatings. Acute (short-term) exposure to dimethylformamide has been observed to damage the liver in animals and in humans.
What can DMF dissolve?
Another significant application is the use of DMF as a solvent for polyurethane-based coatings on leather and artificial leather fabrics. Polymers like polyvinylchloride, vinylchloride- vinylacetate copolymers and some polyamides are also readily dissolved in DMF.
What does DMF do as a reagent?
In addition, DMF usually serves as a solvent in the formation of peptide-bonds. DMF dissolves amino acids and coupling reagents and does not react with piperidine, but this reagent can jeopardize peptide synthesis by decomposition into formaldehyde (HCHO) and dimethylamine (HNMe2).
What is the difference between DMF and DMSO?
DMF is dimethyl formamide while DMSO is dimethyl sulfoxide. Both are organic compounds. The key difference between DMF and DMSO is that DMF is an amide, whereas DMSO is an organosulfur compound. Moreover, DMF is more toxic than DMSO.
Does DMF go through nitrile gloves?
Personal Protective Equipment DMF should always be used in conjunction with proper PPE. This includes safety glasses, gloves, lab coat, long pants and close-toed shoes. Neither latex nor nitrile gloves provide adequate protection against DMF.
How hygroscopic is DMF?
Dimethylformamide (DMF) is a clear, colorless, hygroscopic liquid with a slight amine odor. The solvent properties of DMF are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. The product is known as a universal solvent.
What is the density of DMF?
944 kg/m³
Dimethylformamide/Density