How to treat Kingella?
Treatment of Kingella Infections Kingella organisms are generally susceptible to various penicillins and cephalosporins. However, antimicrobial susceptibility testing is needed to guide therapy. Other useful drugs include aminoglycosides, trimethoprim/sulfamethoxazole, tetracyclines, erythromycin, and fluoroquinolones.
How do you get Kingella?
Kingella kingae is spread person-to-person through respiratory secretions and saliva. Transmission is more likely in child care settings because young children are more likely to harbor the bacteria.
Is Kingella Gram positive or negative?
Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact.
What is a Kingella infection?
Kingella are gram-negative organisms that colonize the human respiratory tract. They cause skeletal infections, endocarditis, and bacteremia and, rarely, pneumonia, epiglottitis, meningitis, abscesses, and ocular infections.
Does clindamycin cover Kingella?
Kingella kingae exhibits relatively high oxacillin MICs (MIC50: 3 mg/ml; MIC90: 6 mg/ml), 40% of invasive isolates are clindamycin nonsusceptible, and all strains are highly resistant toglycopeptide antibiotics, a serious concern in regions where joint and bone infections caused by community-associated methicillin- …
What antibiotic covers Kingella?
Kingella organisms are generally susceptible to various penicillins and cephalosporins. However, antimicrobial susceptibility testing is needed to guide therapy. Other useful drugs include aminoglycosides, trimethoprim/sulfamethoxazole, tetracyclines, erythromycin, and fluoroquinolones.
Is Kingella aerobic?
All species are aerobic, but Kingella and Eikenella spp. also grow under anaerobic conditions.
Does ceftriaxone cover Kingella?
kingae bacteremia and no focal infection generally are administered an intravenous cephalosporin, such as crfuroxime or ceftriaxone, and treatment is subsequently switched to oral b-lactam antibiotics. Patients respond favorably to a 1-2-week antibiotic course (64).
Is there such a thing as Kingella endocarditis?
Kingella endocarditis has been reported in all age groups. Endocarditis may involve native or prosthetic valves.
When is Kingella kingae most common in children?
The most frequent clinical manifestation of invasive K. kingae infection are osteoarticular infections [ 1 ], and K. kingae is the most common cause of such infections in children aged between six months and four years [ 28 ]: one recent molecular study by Ceroni et al.
How is the diagnosis of Kingella infection made?
Diagnosis of Kingella infections requires laboratory isolation from fluids or tissues thought to be infected. Kingella organisms are generally susceptible to various penicillins and cephalosporins.
How is Kingella kingae transmitted from person to person?
K. kingae is transmitted from child to child through close personal contact (eg, at day care centers). Infection has a seasonal distribution, with more cases in fall and winter. Rare manifestations include pneumonia, epiglottitis, meningitis, abscesses, and ocular infections.
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