Does amlodipine cause gingival enlargement?
Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia.
How do calcium channel blockers cause gingival hyperplasia?
The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent.
How common is gingival hyperplasia with amlodipine?
Amlodipine is a second-generation dihydropyridine calcium channel blocker that can cause gingival hypertrophy. The prevalence of amlodipine-induced gingival hypertrophy has been shown to be between 1.7% and 3.3%.
Which drug is responsible for gingival enlargement?
Drugs like PHT, phenobarbitone, and primidone are metabolized to 5-(4-hydroxyphenyl) 5-phenyl hydantoin (4-HPPH), responsible for overgrowth gingival tissue. At times, multiple anticonvulsants are given together, acting synergistically and aggravating the condition.
Does amlodipine cause lip swelling?
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack.
Does amlodipine cause bleeding gums?
In some patients, tenderness, swelling, or bleeding of the gums may appear soon after treatment with this medicine is started. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this.
Do Calcium channel blockers cause gingivitis?
This benign oral condition is a common side effect of the majority of CCBs. It is characterized by an increase of the gingival mass and volume, which can range from mild to extremely severe. Among calcium antagonists, nifedipine is the most frequently implicated antagonist in drug-induced gingival overgrowth.
Do Calcium channel blockers affect the gums?
Calcium channel blockers can cause gingival (gum) overgrowth, said Dr. Michael Quinn, a periodontist who practices at several Coast Dental offices in the Atlanta area. The gums feel swollen, lumpy, hard and thick.
How is drug-induced gingival enlargement treated?
The most effective treatment of drug-related gingival enlargement is withdrawal or substitution of medication. When this treatment approach is taken, it may take from 1 to 8 weeks for resolution of gingival lesions.
What causes gingival enlargement?
Inflammatory gum enlargement Gingival hyperplasia can occur as a direct result of inflammation. The inflammation is often caused by plaque buildup on the teeth from food, bacteria, and poor hygiene practices. The inflammation can make the gums tender and red, and it can trigger bleeding.
Is it safe to take amlodipine for gingival enlargement?
Amlodipine, a commonly used antihypertensive drug, can uncommonly lead to gingival enlargement. It presents as a firm fibrotic growth seen on the gingiva. Careful management by substituting the calcium channel blocker to a relatively safe drug along with oral prophylaxis serve as the first-line treatment of amlodipine-induced gingival enlargement.
What are the side effects of amlodipine enlargement?
Abstract Gingival enlargement is one of the side effects associated with certain drugs. Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia. Amlodipine-induced gingival enlargement is comparatively less prevalent than other calcium channel blocker.
Which is antihypertensive drug causes gingival hyperplasia?
Amlodipine, a calcium channel blocker, used as antihypertensive drug has been found associated with gingival hyperplasia. This case series presents diagnosis and management of amlodipine-induced gingival hyperplasia. Amlodipine-induced gingival enlargement was diagnosed and managed by thorough scaling and root planning.
Are there any drugs that cause gingival enlargement?
Drugs having side effect of gingival enlargement can be broadly divided into three categories: anticonvulsants, calcium channel blockers and immunosuppressants. Many of the calcium channel blockers used as antihypertentive drugs have been implicated in causing gingival enlargement.