Do B cells express CD38?
CD38, a surface protein whose expression increases upon normal B-cell activation, is a marker of disease aggression in B-cell chronic lymphocytic leukemia (B-CLL). Higher percentages of CD38-expressing CLL B cells may be found in lymphoid compartments compared to peripheral blood.
What is CD38 in CLL?
CD38 is a transmembrane glycoprotein expressed on the surface of leukemic cells in a significant percentage of patients with B-cell chronic lymphocytic leukemia (B-CLL). A recent study suggested that CD38 expression has prognostic value in CLL.
What is CD38 a marker for?
CD38 is a multi-functional transmembrane protein that is a lymphocyte receptor and a clinical marker for survival of patients with B-cell chronic lymphocytic leukemia (CLL) [1-5].
What does CD38 stand for?
cluster of differentiation 38
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
What is CD38-positive?
Patients in the CD38-positive cohort were characterised by an unfavourable clinical course with a more advanced disease stage, poor responsiveness to chemotherapy, short time to initiation of first treatment and shorter survival.
How do you stop CD38?
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation.
What is CD38 positive?
What is anti CD38?
A substance that binds to a protein called CD38, which is found on some types of blood cells and in high levels on some cancer cells, including myeloma cells. Anti-CD38 monoclonal antibody may block the CD38 protein and help the immune system kill cancer cells.
What stimulates CD38?
CD38 is expressed predominately on immune cells in response to stimulation by cytokines, endotoxins, and interferon (16–18). Expression of the enzyme is regulated by a promoter region containing binding sites for NF-kB, RXR, LXR, and STAT suggesting that it plays a key role in the inflammatory response (18).
What increases CD38?
Since CD38 is highly expressed in inflammatory cells, it is possible that the low grade inflammation occurring during aging may lead to an increase in the expression of CD38 in inflammatory cells, and accumulation of CD38-positive inflammatory cells in the tissue.
What marker is CD38?
CD38 is a 45 KDa surface glycoprotein, firstly identified as an activation marker (9): successively the molecule was reported as an adhesion molecule, able to interact with endothelial CD31 (10). These finding highlighted the possibility that CD38 may act as a receptor, notwithstanding a structural ineptitude to do so.
How does a proteasome inhibitor work?
Proteasome inhibitors are a type of drug that prevents proteasomes, the garbage disposal system of the cell, from chewing up excess proteins. The proteins build up and kill the myeloma cells.
What is the role of CD38 in B-CLL?
Univariate and multivariate statistical analyses showed that CD38 expression in B-CLL cells can identify a subgroup of patients with significantly more aggressive disease. Two hundred eighteen patients with B-CLL seen at the M. D. Anderson Cancer Center from 1990 to 1999 were included in this study.
Which is an important prognostic factor in B-CLL?
CD38 is a transmembrane glycoprotein expressed on the surface of leukemic cells in a significant percentage of patients with B-cell chronic lymphocytic leukemia (B-CLL). A recent study suggested that CD38 expression has prognostic value in CLL.
How is CD38 expression related to aggressive disease?
Damle et al 18 studied CD38 expression in 37 samples from patients with B-CLL and reported that cells from patients with unmutated immunoglobulin genes were positive for CD38 expression (30% or more of cells), and this was associated with aggressive disease.
Is the CD38 glycoprotein expressed in B cells?
CD38 is a 42kDa membrane glycoprotein expressed in many cell types, including B cells, and has been shown to associate with the BCR in humans. Wolfgang Schuh,