Can interferon cause hyperthyroidism?
Type of Thyroid Dysfunction Induced by IFN. There are three different types of thyroid dysfunction associated with IFN treatment: (1) autoimmune (often subclinical) hypothyroidism; (2) destructive thyroiditis; and (3) Graves’ hyperthyroidism.
Can interferon cause thyroid problems?
Thyroid disease is a frequent side effect of interferon (IFN)-α therapy for hepatitis C virus (HCV) and other disorders, and the clinical approach to this complication is often carried out by personal judgment rather than by defined guidelines.
How is drug induced hyperthyroidism treated?
The drugs used to treat hyperthyroidism or are related to thyroid function that can result in drug-induced hypothyroidism are propylthiouracil, radioactive iodine, potassium iodide, and methimazole. Iodides, in general, alter thyroid function.
Can immunotherapy cause hyperthyroidism?
Hyperthyroidism developed in 2% of patients during immunotherapy and 6% after. Thyroid dysfunction was not a function of sex, diagnosis, type of treatment, or response to immunotherapy.
How does interferon cause hypothyroidism?
IFNα receptor activation results in activation of the JAK-STAT pathway (82), leading to activation of a large number of interferon-stimulated genes (ISGs) including cytokine and adhesion molecule genes (83;84). These combined effects can induce thyroid autoimmunity.
What is the use of alpha interferon?
Alpha interferon is a cytokine produced by the innate immune system in response to environmental exposures including viral infections. Alpha interferon in various formulations has been developed as therapy of several forms of cancer and viral infections, but its major use has been as therapy of chronic hepatitis C.
What is the first line treatment for hyperthyroidism?
Pharmacologic Treatment of Hyperthyroidism
| First-line agents | Dosage |
|---|---|
| Propranolol | Immediate release: 10 to 40 mg orally every eight hours Extended release: 80 to 160 mg orally once per day |
| Antithyroid medications | |
| Methimazole (Tapazole) | 5 to 120 mg orally per day (can be given in divided doses) |
Can Keytruda cause hyperthyroidism?
Hyperthyroidism occurred in 3.4% (96/2799) of patients receiving Keytruda, including Grade 3 (0.1%) and Grade 2 (0.8%). Hyperthyroidism led to permanent discontinuation of Keytruda in <0.1% (2) of patients and withholding of Keytruda in 0.3% (7) of patients.
Does immunotherapy affect your thyroid?
Thyroid Dysfunction During Anti–PD‐1 Immunotherapy Linked to Better Survival Outcomes. There is thought to be a link between autoimmunity and the effectiveness of immunotherapy. Thyroid dysfunction is one of the most common adverse events that may occur during anti–PD‐1 immunotherapy.
What are interferon treatments?
This medication is used to treat various cancers (e.g., leukemia, melanoma, AIDS-related Kaposi’s sarcoma). It is also used to treat virus infections (e.g., chronic hepatitis B, chronic hepatitis C, condylomata acuminata). This medication is the same as a protein that your body naturally produces (interferon).
Can interferon be taken orally?
Interferon-alpha (IFN-alpha) given orally has biological activity in humans and other animals. The dose providing the most benefit delivers IFN-alpha to the oral mucosa in a concentration (10(2)-10(3) IU), similar to that naturally produced in the nasal secretions during respiratory infections.
Is there a natural history of interferon induced thyroiditis?
A small proportion develops interferon-induced thyroiditis of which the long term natural history is unknown and how it compares with de novo thyroiditis. The aim of the study is to determine the natural history of thyroid disease including antibody profile in this particular setting 36 months from the completion of therapy.
What are the effects of interferon alpha on the thyroid?
Interferon induced thyroiditis (IIT) is common among HCV patients treated with interferon-alpha (10;11). Preliminary studies suggest at least two different models by which IFNα may induce thyroid dysfunction, immune-mediated effects and direct thyroid-toxic effects of IFNα.
Are there any side effects of interferon α therapy?
Thyroid disease is a frequent side effect of interferon (IFN)-α therapy for hepatitis C virus (HCV) and other disorders, and the clinical approach to this complication is often carried out by personal judgment rather than by defined guidelines.
Are there any drugs that can cause thyroid dysfunction?
[Drug-induced thyroid dysfunction] Various drugs may cause thyroid dysfunction. The drugs which may cause thyrotoxicosis include interferon, molecular-targeted agents, amiodarone, thyroid hormone itself and so on. Those which cause hypothyroidism include anti-thyroid drugs, lithium and iodine etc. which inhibit thyroid hormone synthe …