Why was debendox taken off the market?
This medication was removed from the market by its manufacturer and was unavailable for many years in the United States because of excessive litigation alleging that Bendectin caused a variety of serious birth defects in children whose mothers took it early in pregnancy.
What kind of birth defects did Bendectin cause?
The first case that received wide publicity was the Mekdeci case, which alleged that Bendectin resulted in a birth defect called Poland syndrome (a deficit in the pectoralis muscle) was filed in 1977. Bendectin accounted for 82 percent of 584,452 antiemetic prescriptions used to treat NVP in the U.S.
Can Diclegis cause birth defects?
There’s no evidence that Diclegis produces birth defects on the scale of a drug like thalidomide, Persaud said, but some concerns do remain about its safety. “No medication is ever going to be perfectly safe,” Persaud said.
Was debendox safe?
First, there is no scientific evidence to suggest that Debendox caused the deformities in children which are complained of.
What were the side effects of debendox?
Debendox
- Acupressure.
- Doxylamine.
- Dicycloverine.
- Antihistaminic Agent.
- Metoclopramide.
- Bendectin.
- Teratogenic Agent.
- Nausea and Vomiting.
What is debendox?
Dicycloverine was formerly combined with doxylamine succinate and sometimes with pyridoxine in Debendox (Bendectin) tablets, which were used in certain countries for the treatment of nausea and vomiting in pregnancy.
What are the ingredients in bendectin?
In its original formulation, Bendectin contained three ingredients: doxylamine succinate (an antihistamine), pyridoxine hydrochloride (vitamin B6) and dicyclomine hydrochloride (an antispasmodic). It became a leading treatment for NVP in the U.S., Canada, as well as internationally under different brand names.
When should I stop taking Diclegis?
If you feel you no longer need Diclegis or do not wish to take it anymore, talk to your doctor. You should not stop the medication cold turkey. The doctor may want to slowly lower your dose over time to prevent nausea and vomiting from coming back.
What are the side effects of Diclegis?
Drowsiness, dizziness, blurred vision, stomach upset, diarrhea, constipation, headache, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.