Which of the following drug is a Thioxanthene?
Thioxanthene Derivatives
| Drug | Target | Type |
|---|---|---|
| Thiothixene | Cytochrome P450 2D6 | enzyme |
| Thiothixene | Dopamine D2 receptor | target |
| Thiothixene | Dopamine D1 receptor | target |
| Thiothixene | 5-hydroxytryptamine receptor 2A | target |
How do Thioxanthenes work?
They work as dopamine-2 (D2) receptor antagonists and suppress the effect of dopamine in the brain. Thioxanthenes are high potency drugs: they have a high affinity for dopamine receptors compared to affinity for adrenergic and muscarinic receptors. Thioxanthene antipsychotics are used to treat schizophrenia.
Which of the following is a Butyrophenone?
Examples of butyrophenone-derived pharmaceuticals include: Haloperidol, the most widely used classical antipsychotic drug in this class. Benperidol, the most potent commonly used antipsychotic (200 times more potent than chlorpromazine) Droperidol, Antiemetic for postoperative nausea and vomiting.
What is the basic pharmacology of Thioxanthene?
Thioxanthene: One of a group of drugs with antipsychotic activity which act by blocking postsynaptic (after-the-nerve) receptors for dopamine (a chemical that nerves use to communicate with one another) in the brain. Examples include: thiothixene (brand name: Navane), chlorprothixene (Remeron) and flupenthixol.
What class of drug is loxapine?
Loxapine is in a group of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.
What is the most powerful antipsychotic?
Clozapine, which has the strongest antipsychotic effect, can cause neutropenia. A problem in the treatment of schizophrenia is poor patient compliance leading to the recurrence of psychotic symptoms.
Is haloperidol a Butyrophenones?
Butyrophenones. Haloperidol and droperidol are butyrophenones with antipsychotic effects used in the treatment of psychosis and agitation associated with schizophrenia and mania. They have antiemetic properties as dopamine-2 receptor antagonist (Table 25.1).
What are FGA drugs?
First-generation antipsychotics (FGAs) are drugs used primarily for the treatment of schizophrenia and related psychotic disorders. The use of FGAs has declined in the last few years, mainly because of an increase in prescriptions of second-generation agents.
What is loxapine used to treat?
Loxapine is used to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Loxapine is in a group of medications called conventional antipsychotics. It works by decreasing abnormal excitement in the brain.