What type of diuretic is eplerenone?
Synopsis: Eplerenone, a potassium-sparing diuretic similar to spironolactone, selectively blocks aldosterone to lower blood pressure. However, its safety profile is improved over spironolactone because of reduced progesterone and androgen-receptor effects.
Which diuretic is used for treatment of hyperaldosteronism?
Spironolactone is the agent most commonly used to treat hyperaldosteronism because it directly antagonizes aldosterone effects at the distal tubule.
What is the best potassium-sparing diuretic?
Examples of potassium-sparing diuretics include:
- Amiloride (Midamor)
- Eplerenone (Inspra)
- Spironolactone (Aldactone, Carospir)
- Triamterene (Dyrenium)
Can you take eplerenone and furosemide together?
No interactions were found between eplerenone and Lasix. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Do thiazide diuretics cause hyperkalemia?
Hyperkalemia is a leading complication of the potassium-sparing agents, especially in patients with an underlying tendency for hyperkalemia. Thiazide diuretics, in particular, have been linked to glucose intolerance, which may be an effect of hypokalemia rather than the diuretic itself.
Are thiazide diuretics potassium sparing?
Thiazide / potassium-sparing diuretic combinations are used to treat hypertension, heart failure, and edema. They work by causing the kidneys to get rid of excess salt and water while retaining potassium.
Is eplerenone a good diuretic?
Eplerenone and spironolactone increase natriuresis and cause renal retention of potassium when plasma aldosterone is high, i.e., both agents are facultative diuretics. Eplerenone reduces high blood pressure effectively.
How does thiazide like diuretics affect the nephron?
Thiazide and thiazide-like diuretics act on the nephron mainly at the proximal part of the distal tubule. Sodium excretion and urine volume are increased by interference with transfer across cell membranes. The result is a reduction in blood volume.
What is the moa of thiazide diuretics?
The MOA of thiazide diuretics is to decrease sodium reabsorption and therefore decreased fluid reabsorption; this directly causes decreased levels of circulating sodium.
Which is better chlorthalidone or thiazide diuretics?
The use of longer acting thiazide-type or thiazide-like diuretics, such as chlorthalidone, appears to be superior to the shorter acting hydrochlorothiazide in preventing some renal and cardiovascular consequences of hypertension.
What is the difference between furosemide and thiazide?
In contrast, furosemide (which does not promote reabsorption of calcium in the distal tubule) causes transient hypercalciuria, an effect that has been exploited on occasion in the treatment of hypercalcemia [145 ]. Hypercalcemia associated with thiazide diuretics is probably due to reduced urine calcium excretion.