What is the use of Voluven?
What is Voluven used for. Voluven is a plasma volume substitute that is used to restore the blood volume when you have lost blood when other products called crystalloids are not considered sufficient alone. It is not a substitute for blood or blood containing products.
Why is Voluven contraindicated in sepsis?
Contraindications. Do not use hydroxyethyl starch (HES) products, including Voluven ®, in critically ill adult patients, including patients with sepsis, due to increased risk of mortality and renal replacement therapy (RRT).
Is Voluven a hetastarch?
The ratio Voluven®/hetastarch was estimated as 1.024 with a 95% confidence interval (0.84, 1.25), which was included within the equivalence range of (0.55, 1.82) prespecified in the study protocol.
What is hydroxyethyl starch used for?
Hydroxyethyl Starch is a plasma volume substitute used to treat and prevent hypovolemia. Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.
What is Tetrastarch?
What Is Tetrastarch and How Does It Work? Tetrastarch is used for treatment and prophylaxis of low blood volume (hypovolemia). Tetrastarch is available under the following different brand names: Voluven.
Is Voluven a colloid or crystalloid?
Anesthesiol Clin.
Is blood colloid or crystalloid?
Crystalloids are aqueous solutions of mineral salts or other water-soluble molecules. Colloids contain larger insoluble molecules, such as gelatin; blood itself is a colloid. There is no evidence that colloids are better than crystalloids in those who have had trauma, burns, or surgery.
What is a hydroxyethyl group?
2-hydroxyethyl group (CHEBI:44730) is substituent group from ethanol (CHEBI:16236) IUPAC Name. 2-hydroxyethyl. Synonyms. Sources.
Is hydroxyethyl starch a plasma expander?
HES are synthetic colloid solutions used as plasma volume expanders in a range of clinical settings, including hypovolaemia. Also, there is no evidence that HES solutions used for plasma volume expansion provide additional clinical benefits to patients when compared with crystalloids. …
Can we drink normal saline?
Do not drink saline. Use table salt or fine sea salt. Coarse salt doesn’t dissolve as well and can cause irritation. Do not use saline to clean or store your contact lenses.
What is saline injection?
Normal Saline (sodium chloride) Injection is a fluid and electrolyte replenisher used as a source of water and electrolytes. Normal Saline is available in generic form.
How is the HeS component of Voluven characterized?
The HES component of Voluven (6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride injection) is characterized by its medium molecular weight (130,000) and degree of molar substitution (0.4) on the glucose units of the starch. In this submission, the sponsor has conducted 3 pharmacokinetic studies of voluven:
How many people have been exposed to Voluven?
During clinical development, a total of 899 subjects received the hydroxyethyl starch 130/0.4 drug substance contained in Voluven ® at different concentrations (2%, 4%, 6%, or 10%) and at cumulative doses of several mL up to 66 L. 2 Of these 899 subjects, 602 were exposed to Voluven ® (i.e., 6% hydroxyethyl startch 130/0.4).
How much Voluven is needed for 70 kg patient?
This dose is equivalent to 3500 mL of Voluven ® for a 70 kg patient. The dosage in children should be adapted to the individual patient colloid needs, taking into account the disease state, as well as the hemodynamic and hydration status. In 41 newborns to infants (< 2 years), a mean dose of 16 ± 9 mL/kg was administered.
What is Fresenius Kabi’s new HES product Voluven?
Fresenius Kabi has developed a new HES product (Voluven) with the intent of improving the safety profile of HES with no reduction in efficacy.