What is the other alternative method for the preparation of Benzhydrol?
Diphenylmethanol may be prepared by a Grignard reaction between phenylmagnesium bromide and benzaldehyde. An alternative method involves reducing benzophenone with sodium borohydride or with zinc dust or with sodium amalgam and water.
Can NaBH4 reduce acetals?
This reaction is used in synthesis to protect carbonyls from reaction. Aldehydes are more reactive than ketones. The acetal will not react with NaBH4, so only the ketone will get reduced.
Which of the following is reduced by sodium borohydride?
Sodium borohydride is a relatively selective reducing agent. Ethanolic solutions of sodium borohydride reduce aldehydes and ketones in the presence of epoxides, esters, lactones, acids, nitriles, or nitro groups. Reduction of aldehydes is straightforward.
Which of the following is not reduced by sodium borohydride?
By itself, it will generally not reduce esters, carboxylic acids, or amides (although it will reduce acyl chlorides to alcohols). It is also used in the second step of the oxymercuration reaction to replace mercury (Hg) with H.
What is Benzhydrol used for?
Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group.
Which groups are reduced by NaBH4?
Sodium borohydride It is only powerful enough to reduce aldehydes, ketones and acid chlorides to alcohols: esters, amides, acids and nitriles are largely untouched.
What does NaBH4 reduce?
Sodium borohydride NaBH4 is less reactive than LiAlH4 but is otherwise similar. It is only powerful enough to reduce aldehydes, ketones and acid chlorides to alcohols: esters, amides, acids and nitriles are largely untouched. It can also behave as a nucleophile toward halides and epoxides.
What does NaBH4 and MeOH do?
The NaBH4-MeOH system, formed by the addition of methanol to sodium borohydride in refluxing THF, reduces esters to the corresponding alcohols.
What is Benzhydrol soluble in?
water
Solubility : Soluble in water (0.5 mg/ml at 20° C), chloroform, alcohol, ether, and methanol. Melting Point : 65-67° C (lit.)