What is pH responsive drug delivery system?
pH-Responsive drug-delivery systems have attracted more and more interest as “smart” drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy.
What polymers are used in drug delivery?
Among the synthetic and biodegradable polymers, aliphatic polyesters such as poly (glycolic acid), poly (lactic acid), poly (caprolactone) and polydioxanone, are most commonly used and applied to drug delivery systems.
How are polymers used in drug delivery system?
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
How does different pH in the body affect drug delivery?
Having pH-sensitivity, cationic polymers can mask the taste of drugs and release drugs in the stomach by responding to gastric low pH. Anionic polymers responsive to intestinal high pH are used for preventing gastric degradation of drug, colon drug delivery and achieving high bioavailability of weak basic drugs.
How polymers are effective in controlled drug delivery system?
The only structure effectively limiting the release of the drug is the polymer layer surrounding the reservoir. Since this polymer coating is essentially uniform and of a nonchanging thickness, the diffusion rate of the active agent can be kept fairly stable throughout the lifetime of the delivery system.
Which polymer is mostly used in pharmaceutical formulation?
polymer polysaccharide, gummy exudates are the natural polymers which are used in formulating pharmaceutical products. are chitosan, carrageenan, isapghula, acacia, gelatin, agar, shellac, guar gum.
What is a benefit of using polymers for drug delivery?
There are several advantages of polymer acting as an inert carrier to which a drug can be conjugated, for example, the polymer improves the pharmacokinetic and pharmacodynamic properties of biopharmaceuticals through various ways, such as, increases the plasma half-life, decreases the immmunogenicity, boost stability …
How does pH in the body affect drug delivery?
How does pH affect drug stability?
In addition to temperature, pH is also a factor that affects the stability of a drug prone to hydrolytic decomposition. Drug stability can frequently be improved though the use of buffering agents between pH 5 and pH 6. Oxidation is another destructive process that produces instability in drug products.
What are the applications of pH responsive polymers?
The subject of pH-responsive polymers has become very popular in recent years and new studies have been added year after year. These unique properties of pH-responsive polymer systems consequently make them very useful in various applications such as drug delivery, gene delivery, sensors, surfaces, membranes, and chromatography. 4–6
How are pH sensitive polymers used in medicine?
Through suppressing drug release in the oral cavity, taste-masking formulations can prevent the unpleasant tastes of drugs as the polymers are insoluble at higher pH. While being more soluble at lower pH, pH-sensitive polymers can release the drugs in the stomach or intestine for drug absorption or therapeutic purposes at the released sites.
How are responsive polymers used in drug delivery?
RESPONSIVE POLYMERS FOR DRUG DELIVERY. Physical stimuli (i.e., temperature, ultrasound, light, and magnetic and electrical fields) directly modulate the energy level of the polymer/solvent system and induce a polymer response at some critical energy level. Chemical stimuli (i.e., pH, redox potential, ionic strength,…
How are cationic polymers used in drug delivery?
Areas covered. Having pH-sensitivity, cationic polymers can mask the taste of drugs and release drugs in the stomach by responding to gastric low pH. Anionic polymers responsive to intestinal high pH are used for preventing gastric degradation of drug, colon drug delivery and achieving high bioavailability of weak basic drugs.