What is mucoadhesive drug?
Mucoadhesive drug delivery systems are delivery systems which utilize the property of bioadhesion of certain polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time.
What is used as a mucoadhesive polymer?
The various mucoadhesive polymers which have been used for the development of oral delivery systems include chitosan, poly(acrylic acid), alginate, poly(methacrylic acid) and sodium carboxymethyl cel- lulose [62].
What is the characteristic of mucoadhesive?
Other desired characteristics of a mucoadhesive dosage form include high drug loading capacity, controlled drug release (preferably unidirectional release), good mucoadhesive properties, smooth surface, tastelessness, and convenient application.
Which one the following is an example of natural mucoadhesive polymer?
Various natural polymers which can be used in mucoadhesive buccal films are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc.
What is mucoadhesive drug delivery system Slideshare?
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. Mucoadhesive drug delivery system is a part of controlled delivery system.
What leads to drug release from an Electroresponsive system?
In addition, drug release must be directly triggered by an electric stimulus, and not indirectly such as by a change of local pH caused by the electro-oxidation/reduction of water (or dissolved oxygen),23 or by chemical oxidants or reducing agents.
Why are drugs encapsulated?
Encapsulation is commonly adopted in drug delivery systems to form a shell to protect a particular drug, and prevent it from leaching out before reaching the targeted site. The shell is usually made of hydrogel matrices or polymeric nanostructures that are able to entrap the targeted drug.
What are the different types of Bioadhesion?
Examples of bioadhesives in nature
- Colonization of surfaces (e.g. bacteria, algae, fungi, mussels, barnacles, rotifers)
- Mussel’s byssal threads.
- Tube building by polychaete worms, which live in underwater mounds.
- Insect egg, larval or pupal attachment to surfaces (vegetation, rocks), and insect mating plugs.
What is the characteristic of mucoadhesive systems in Grdds?
Mucoadhesive formulations contain adhesive biopolymers that adhere to the mucosa covering the stomach inner wall and release their API in a sustained manner [7][8][9][10]. …
What are the names of the mucoadhesive polymers?
Natural mucoadhesive polymers: Tragacanth, Sodium alginate, Karaya gum, Guar gum, Xanthan gum, Soluble starch, Gelatin, Pectin, Chitosan, etc. delivery of macromolecular pharmaceuticals via active cell
How is mucoadhesion used in buccal drug delivery?
Aiming to optimize the pharmacokinetic, buccal mucoadhesive drug delivery systems are proposed. Mucoadhesion is a complex process involving chemical interactions between mucin and polymers. The success and degree of mucoadhesion bonding is based on various polymer-based features.
Which is the best mucoadhesive for oral use?
Polyacrylates are available in a wide range of molecular weights, form transparent, easily modified gel networks, are non-toxic and are considered safe (GRAS status) for oral use by the FDA. Among PAA derivatives, polycarbophil (Noveon®) and carbomer (Carbopol®) have been extensively studied as mucoadhesive platforms for drug delivery [20].
What makes poly acrylic acid a good mucoadhesive?
They are polymers of acrylic acid cross-linked with polyalkenyl ethers or divinylglycol. Poly (acrylic acid) (PAA) possesses excellent mucoadhesive characteristics due to the ability of the carboxylic groups to form strong hydrogen bonds with the oligosaccharide chains of mucin.