What is MnSOD?
Manganese superoxide dismutase (MnSOD), an enzyme located in mitochondria, is the key enzyme that protects the energy-generating mitochondria from oxidative damage. Levels of MnSOD are reduced in many diseases, including cancer, neurodegenerative diseases, and psoriasis.
Where is SOD2 produced?
mitochondrial matrix
SOD2 is located within the mitochondrial matrix, the main site of free radical production from the electron transport chain (22).
Where is SOD2 made?
mitochondria
There are a three forms of SOD: SOD1, SOD2 and SOD3. SOD1 is located in the cellular fluid, SOD2 in the mitochondria, and SOD3 outside the cell. Superoxide is one of the main reactive oxygen species in the cell.
Where is Sod 1 found?
SOD1 functions as an antioxidant protein and is ubiquitously expressed with predominant localization in the cytoplasm but it is also localized within mitochondria,373,374 the nucleus,375 and the ER. Presently, over 150 mutations in the SOD1 gene have been identified in association with FALS.
How does SOD2 work?
SOD regulates mitochondria function by above function (i.e., scavenging O2•−, producing H2O2, inhibition of production of ONOO− by protecting NO) in the mitochondrial matrix (SOD2) and in the intermembrane space (SOD1). ROS in mitochondria are produced by oxidative phosphorylation pathway involved in energy production.
Is SOD2 a protein?
SOD2 (Superoxide Dismutase 2) is a Protein Coding gene. Diseases associated with SOD2 include Microvascular Complications Of Diabetes 6 and Gastric Cancer.
What is a mitochondrial superoxide dismutase?
Mitochondrial superoxide dismutase (SOD2) is a major component of the metabolic machinery that handles reactive oxygen species (ROS) in the mitochondrial matrix. Specifically, SOD2 determines how much superoxide radical anion (O2•−) is converted to hydrogen peroxide (H2O2) (42, 90, 129) (Fig. 1).
What is superoxide dismutase2?
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen.
What mutations cause ALS?
Worldwide, SOD1 gene mutations cause 15 to 20 percent of familial ALS, and TARDBP and FUS gene mutations each account for about 5 percent of cases. The other genes that have been associated with familial ALS each account for a small proportion of cases.