What is a normal total protein level in pregnancy?
Definition
| Test | Nonpregnant Range | Pregnancy Effect |
|---|---|---|
| Protein (total) | 6.5–8.5 g/dL | 1 g/dL decrease |
| Sodium | 135–145 mEq/L | 2–4 mEq/L decrease |
| Urea nitrogen | 12–30 mg/dL | 50% decrease |
| Uric acid | 3.5–8 mg/dL | 33% decrease |
What is a normal protein S level?
These percentage values should usually fall between 60 and 150. There might be slight differences among testing facilities. High levels of protein S are not typically cause for concern, whereas low levels may increase your risk of blood clots.
Is protein S affected by pregnancy?
Protein S is a cofactor of protein C which lowers the activated factors VIII and V. Pregnancy reduces the level of protein S to 40-50% of normal levels but it is not clear whether the lowered protein S levels increase the risk of developing thrombo-embolism during pregnancy.
Does protein S go up or down in pregnancy?
Free protein S levels fell significantly from first to second trimesters (0.45 U/ml mean to 0.26 U/ml mean, p < 0.001), but no further fall occurred during the third trimester. Conclusions: The second-trimester fall in free protein S levels is a physiologic pregnancy adaptation.
What is a low total protein level?
If your total protein level is low, you may have a liver or kidney problem, or it may be that protein isn’t being digested or absorbed properly. A high total protein level could indicate dehydration or a certain type of cancer, such as multiple myeloma, that causes protein to accumulate abnormally.
What if S protein is high?
Elevated protein S levels are not usually associated with medical problems and are not clinically significant. Normal protein C and protein S antigen activity and concentrations usually indicate adequate clotting regulation. A low level of protein S activity can cause excessive or inappropriate blood clotting.
What is a low level of protein S?
Protein S deficiency is a disorder of blood clotting. People with this condition have an increased risk of developing abnormal blood clots. Individuals with mild protein S deficiency are at risk of a type of clot called a deep vein thrombosis (DVT) that occurs in the deep veins of the arms or legs.
What does low protein S levels mean?
What is protein S function?
Protein S is involved in many cellular activities, including inhibition of the blood coagulation cascade, inhibition of inflammation, clearance of apoptotic bodies, angiogenesis and cell survival. Protein S functions as an anticoagulant by inhibiting FIXa and by serving as a cofactor for APC and TFPI.
What should your protein level be during pregnancy?
Negative Pregnancy Adult: 6.7 to 8.6 g/dL or 67 to 86 g/L Pregnancy Trimester One: 6.2 to 7.6 g/dL or 62 to 76 g/L Pregnancy Trimester Two: 5.7 to 6.9 g/dL or 57 to 69 g/L Pregnancy Trimester Three: 5.6 to 6.7 g/dL or 56 to 67 g/L
When does total protein’s reach the adult level?
Normal, full-term newborn infants or healthy premature infants may have decreased levels of total protein S (15-50%); but because of low levels of C4b-binding protein, free protein S may be normal or near the normal adult level (> or =50%). Total protein S reaches adult levels by 90 to 180 days postnatal.
When to test for protein’s in babies?
However, because the neonatal reference range is very wide, repeat testing at 6 months may be required for heterozygous or type II or III deficiency. Alternatively, evaluations for other vitamin K–dependent coagulation proteins can be performed for comparison or parental levels of protein S can be measured.
What should your globulin level be during pregnancy?
Globulin testing is associated with infection or blood disease. Normal Value Range. Negative Pregnancy Adult: 6.7 to 8.6 g/dL or 67 to 86 g/L. Pregnancy Trimester One: 6.2 to 7.6 g/dL or 62 to 76 g/L. Pregnancy Trimester Two: 5.7 to 6.9 g/dL or 57 to 69 g/L.