What cells express IRF8?
Nonetheless, a number of studies have shown that IRF8 is expressed in a variety of non-lymphoid tissues including the mouse lens [32, 33], developing mouse brain [34], human retinal pigment epithelial cells [35], mature human spermatozoa [36], a human osteosarcoma cell line [37], and human colon adenocarcinoma cell …
What is IFN 8?
IFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation. Whether IRF8 plays a role in the development and function of microglia, the tissue-resident myeloid cells of the brain, is unknown.
Which cell types are missing in IRF8 individuals?
In humans with the IRF8 K108E mutation, peripheral blood myeloid DCs, plasmacytoid DCs and monocytes are completely lost. In mice with an IRF8 mutation, the predominant defect is in CD8+CD103+ DCs, with apparent preservation of CD11b+ DCs and monocytes.
Is Pegasys interferon an immunosuppressant?
Pegasys injection contains the active ingredient peginterferon alfa-2a, which is a type of medicine called an immunomodulator. It is a man-made form of a natural substance called interferon.
What do the interleukins do?
interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells. Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation.
Is Pegasys an immunotherapy?
Peginterferon alfa-2a (Pegasys®) is an Immunotherapy Regimen for Polycythemia Vera.
Who makes Pegasys interferon?
Genentech: Pegasys® (peginterferon alfa-2a) – Information for Patients.
What is the meaning of lymphokines?
Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte. They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines aid B cells to produce antibodies.
What is the function of the IRF8 gene?
The IRF8 gene polymorphisms might be associated with susceptibility to SLE. Data demonstrate a novel function for ICSBP in epithelial-mesenchymal transition, cell motility, and invasion through the TGF-beta and Snail signaling pathways.
How does IRF5 and IRF8 control TLR9 signaling?
IRF5 and IRF8, two transcription factors with opposing functions, control TLR9 signaling in human plasmacytoid dendritic cells. cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224, which can counteract the repressive activity of WT1 on the IRF8-promoter
How does IRF3 and IRF8 regulate NF-κB signaling?
We determined that IRF3 and IRF8 can regulate MyD88-mediated NF-κB signaling pathway in fish. Interestingly, MyD88 is precisely regulated by IRF3 and IRF8 through the same mechanism but in completely opposite ways.
How is MyD88 regulated by IRF3 and IRF8?
Overall, both IRF3 and IRF8 regulate the expression of MyD88 in opposite ways via the same ubiquitin–proteasome degradation. IRF3 and IRF8 can tightly regulate and stabilize MyD88-mediated NF-κB signaling pathway to maintain immune intensity and immune homeostasis at different stages.