Is there any treatment for CMV infection in pregnancy?
There’s currently no treatment for CMV in pregnancy, but in most cases the virus does not cause any problems for your baby. Antiviral medicine may be used to treat: babies diagnosed with congenital CMV after they’re born. people with a weakened immune system.
Does ganciclovir cover CMV?
Ganciclovir and valganciclovir are used primarily in treating cytomegalovirus (CMV) infections. In vitro synergy with foscarnet has been observed against CMV [3].
What happens if cytomegalovirus IGG is high in pregnancy?
What are the signs and symptoms of CMV during pregnancy? Most CMV infections in pregnant women are “silent” and cause no symptoms. When symptoms do occur, they most commonly are fever, sore throat, swollen lymph glands and extreme fatigue. Rarely, a rash, cough or diarrhea may occur.
What medication is used to treat CMV?
There are currently four antiviral drugs licensed for the treatment of CMV infections: ganciclovir (GCV), valganciclovir (VGCV), foscarnet (FOS), and cidofovir (CDV).
Are there any patients who are resistant to ganciclovir?
During the AIDS epidemic, the development of ganciclovir resistance was reported among patients with AIDS who were receiving prolonged ganciclovir therapy for CMV retinitis. Furthermore, studies demonstrated that in vitro resistance to ganciclovir was associated with clinical progression of CMV disease [1–4].
What to do with congenital CMV infection in pregnancy?
Once the diagnosis of congenital CMV infection is confirmed, one option is pregnancy termination. A second proposed option has been treatment of the mother with antiviral agents such as ganciclovir, foscarnet, and cidofovir. These drugs are of moderate effectiveness in treating CMV infection in the adult, particularly the immunocompromised patient.
When to use barrier contraception after taking ganciclovir?
Ganciclovir Pregnancy Warnings. -Females of reproductive potential should undergo pregnancy testing before starting therapy and use effective contraception during therapy and for at least 30 days after the last dose. -Male patients should be advised to use barrier contraception (condoms) during and for at least 90 days after their last dose.
Is it safe to breastfeed while taking ganciclovir?
Ganciclovir Breastfeeding Warnings. Breastfeeding is not recommended during use of this drug. Comments: -Breastfeeding is not recommended because of the potential for this drug to cause serious toxicity in a nursing infant. -The US CDC advises HIV-infected women not breastfeed so as to avoid potential postnatal transmission of HIV.