Are gene names capitalized?
Note that full names of genes and proteins start with a lower-case letter unless they begin with a person’s name (describing a disease/phenotype) or a capitalized abbreviation.
What is the name of Bcl-2?
B-cell lymphoma 2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
How do you write gene names?
General rules:
- Full gene names are italicized, all lower case, NEVER use Greek symbols. eg: cyclops (in italics)
- Gene symbols are italicized, all lower case. eg: cyc (in italics)
- Protein designations are the same as the gene symbol, but first letter only upper case and not italicized. eg: Cyc.
Is Bcl-2 a gene?
BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include Follicular Lymphoma 1 and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement. Among its related pathways are TNFR1 Pathway and CNTF Signaling.
Is gene a girl name?
Gene Origin and Meaning The name Gene is a girl’s name. This is still usually the boy’s spelling.
Are promoters italicized?
Like the gene name, the mRNA and cDNA names should be in italics. For example, if you write “The FLC gene promoter”, having FLC in italics indicates that you mean the gene, so the word “gene” is redundant here.
What chromosome is BCL2 on?
The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas.
What does BCL6 positive mean?
Christopher: “A positive result indicates the presence of inflammation in the uterine lining most commonly associated with endometriosis. The test measures the levels of a certain marker called BCL6 in endometrial tissue.
What does Bcl-2 gene do?
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis.
What are Bcl-2 inhibitors?
A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells.
Is gene a French name?
Gene is a short form of Eugene, a name brought to England by way of the Norman-French after the Conquest of 1066. It’s the Old French equivalent of the Greek Ευγενιος (Eugenios) from “eugenēs” meaning “well born, noble” (from the elements eu- “good” and genos “birth”).
Who is named gene?
Danish botanist Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity.
What are the diseases associated with the BCL2 gene?
BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Diseases associated with BCL2 include High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement and Follicular Lymphoma 1 . Among its related pathways are Direct p53 effectors and Amyotrophic lateral sclerosis (ALS) .
Where does the protein Bcl-2 get its name from?
Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas.
When does the BCL2 protein cause cell death?
Cells undergo apoptosis when they have reached the end of their natural life cycle, when they become damaged, or if they mutate [ R ]. The Bcl-2 protein triggers cell death by disrupting the mitochondrial membrane [ R ].
What does UniProtKB do for the BCL2 gene?
UniProtKB/Swiss-Prot for BCL2 Gene. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability.