What is TTF-1 a marker for?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas.
What is TTF-1 positive in lung cancer?
In clinical practice, TTF-1 is most commonly used to distinguish primary lung ADC from non-pulmonary cancers that have metastasized to the lung 44. TTF-1 expression by IHC has been detected in up to 95% of ADC of the lung, depending on the techniques, cut-off value of positive staining, and stage 29,37.
Is TTF-1 a biomarker?
Studies suggest that TTF-1 is a potential biomarker for differentiating pulmonary adenocarcinomas from non-pulmonary adenocarcinomas in pleural or other effusions11,12,13, but results from these studies have not always been consistent.
What does TTF 1 negative mean?
Background: Patients with thyroid transcription factor 1 (TTF1) negative lung adenocarcinoma (ADC) have been reported to have a worse prognosis and to lack epidermal growth factor receptor (EGFR) mutations. This study describes a series of sample tumors from patients with clinically confirmed lung cancer.
What is TTF-1 and Napsin A?
TTF-1 has been the premier marker for lung adenocarcinoma. A new and promising marker, Napsin A, is expressed in type II pneumocytes and in adenocarcinomas of the lung (2). Studies have shown Napsin A to be more sensitive and specific than TTF-1 in lung adenocarcinomas and virtually negative in all squamous carcinomas.
What does CDX2 positive mean?
These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.
Is NSCLC adenocarcinoma aggressive?
Adenocarcinoma of the lung (a type of non-small cell lung cancer) is fairly aggressive. Even early diagnosis offers only a 61% chance of survival five years later.
Where is TTF-1 expressed in the body?
INTRODUCTION. Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing nuclear transcription factor which belongs to the Nkx2 gene family; it is expressed in the forebrain, thyroid and lung. TTF-1 plays a key role in morphogenesis of the lungs[ 1] and is expressed in up to 90% of pulmonary small cell carcinoma[ 2 ].
What is the role of TTF-1 in lung cancer?
Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing nuclear transcription factor which belongs to the Nkx2 gene family; it is expressed in the forebrain, thyroid and lung. TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2].
How many cases of TTF-1 Mab are there?
Seven of the 13 cases contained non-neoplastic parenchymal lung tissue, which labelled strongly with both TTF-1 MAbs, serving as an internal quality control.
Are there any TTF-1 positive gastric carcinoids?
Two primary gastric carcinoid tumours were TTF-1 positive, one in the series of Kaufmann et al[10] and one in the series of Cai et al[8]. With regard to high-grade endocrine tumours (small cell cancers), the situation is, however, quite different.