What is meant by antigenic shift?

What is meant by antigenic shift?

Another type of change is called “antigenic shift.” Shift is an abrupt, major change in a flu A virus, resulting in new HA and/or new HA and NA proteins in flu viruses that infect humans. Antigenic shift can result in a new flu A subtype.

Is drift or antigenic shift worse?

Because the genes in the resulting virus are dramatically different, this is called antigenic shift. Antigenic shift is more concerning than antigenic drift. Antigenic shift can produce a version of influenza virus that no person’s immune system has antibodies to protect against.

How does antigenic shift occur?

Antigenic shift occurs when an influenza A virus acquires HA or NA components that differ from antecedent strains by a quantum jump.

Is influenza antigenically stable?

Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs. mBio.

What is antigenic shift with example?

An example of a pandemic resulting from antigenic shift was the 1918-19 outbreak of Spanish Influenza. This strain was originally the H1N1 avian flu, however antigenic shift allowed the viral infection to jump from pigs to humans, resulting in a large pandemic which killed over 40 million people.

What is genetic shift and drift?

A small change to the genetic makeup of influenza strains is referred to as antigenic drift, while a major change is called antigenic shift.

What is the best example of an antigenic shift?

Is hemagglutinin a lectin?

This envelope contains two critical membrane glycoproteins, hemagglutinin (HA) and neuraminidase (NA). HA is the lectin that mediates the viral entry in the host cell.

What is the route of transmission for influenza?

Person to Person. People with flu can spread it to others up to about 6 feet away. Most experts think that flu viruses spread mainly by droplets made when people with flu cough, sneeze or talk. These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs.

What is the difference between antigenic shift and drift?

Influenza Virus are remarkable because of the frequent antigenic change that occurs in HA (hemagglutinin) or NA (neuraminidase)….Differences Between Antigenic Shift and Antigenic Drift.

S.N.	Antigenic Shift	Antigenic Drift
7	Occurs as a results of genome reassortment between difference subtypes.	Occurs as a result of the accumulation of point mutations in the gene.