What is Lipin deficiency?
The Lipin-1 deficiency is an inherited autosomal recessive disease caused by two mutations in the LPIN1 gene. Homozygous or compound heterozygous Lipin-1 deficiency causes recurrent acute episodes of rhabdomyolysis and myoglobinuria in children, associated with permanent muscle pain and weakness.
What is a Lipin?
Lipins are eukaryotic proteins with functions in lipid synthesis and the homeostatic control of energy balance. They execute these functions by acting as phosphatidate phosphatase enzymes in the cytoplasm and by changing gene expression after translocation into the cell nucleus, in particular under fasting conditions.
What means Lupin?
Lupine comes from lupus, Latin for “wolf”, and its related adjective lupinus, “wolfish”. Lupine is also a noun, the name of a well-known garden flower, which was once thought to drain, or “wolf”, the soil of its nutrients.
What role does Lipin 1 play in phospholipid synthesis?
By converting PA to DAG, lipin-1 controls the synthesis of major phospholipids. In addition to its function as a PAP on the ER that regulates phospholipid synthesis, lipin-1 can function as a transcriptional coactivator to regulate the expression of genes for fatty acid oxidation (20, 28).
What is lupine disease?
Brown spot – Leaves, stems, and seed pods can all develop brown spots and cankers and suffer premature dropping. The disease is spread through spores that live in the soil under plants. After an outbreak of brown spot, don’t plant lupines in the same location again for several years to give the spores time to die out.
What is lupine behavior?
BEHAVIOR: Lupine is a legume so it adds nitrogen to the soil. It may grow in a semi-‐prostate position, but flower stalks are straight up. The seed pods are 1 to 2 inches long and “explode” when ripe, spreading several seeds a distance from the plant.
How might phospholipid synthesis affect cell viability?
Conceivably, inhibition of phospholipid synthesis would reduce the levels of phospholipids required for membrane biogenesis and signaling molecules in cancer cells, therefore inhibiting their proliferation or viability.
What conditions do lupines like?
Light: Full sun is preferred. Lupine can grow in part shade, but flowering will be lessened. Soil: Lupine needs well-draining soil above all else. It prefers soil on the acid side and will not tolerate high levels of alkalinity or water-logged conditions.
What conditions do lupins like?
Where to grow lupins. Lupins do best in full sun or dappled shade, in moist but well-drained soil. Like many other perennials with tall flowers, lupins benefit from a sheltered position.
What is lupine allergy?
Allergic reactions to lupin cause similar symptoms seen with other food allergens and may include hives, oral itching, swelling of the face, tongue or throat, abdominal pain, nausea, vomiting, runny nose or watery eyes, difficulty breathing, cough, wheeze, and cardiovascular symptoms, such as low blood pressure [2].
What does lupine look like?
Lupines, with their colorful spikes, are some of the most popular garden perennials of them! Growing 1 to 4 feet tall, the leaves of lupine are grey-green with silvery hairs and the flowers resemble pea flowers. The seed pod looks like a hairy pea pod and contains up to 12 seeds.
What are the signs and symptoms of ovarian cancer?
Others symptoms of ovarian cancer can include: Fatigue (extreme tiredness) Upset stomach. Back pain. Pain during sex. Constipation. Changes in a woman’s period, such as heavier bleeding than normal or irregular bleeding.
How to know if you have primary ovarian insufficiency disease?
They include: 1 Irregular or skipped periods, which might be present for years or develop after a pregnancy or after stopping birth control pills 2 Difficulty getting pregnant 3 Hot flashes 4 Night sweats 5 Vaginal dryness 6 Dry eyes 7 Irritability or difficulty concentrating 8 Decreased sexual desire
What are the symptoms of premature ovarian failure?
Symptoms. Signs and symptoms of premature ovarian failure are similar to those of going through menopause and are typical of estrogen deficiency. They include: Irregular or skipped periods (amenorrhea), which might be present for years or develop after a pregnancy or after stopping birth control pills.
What is the role of LPIN1 in breast cancer?
It seems that a new signaling axis, SIRT1-SFRS10-LPIN1 axis, acting in the pathogenesis of alcoholic fatty liver disease exists. Consistent with these observations, LPIN1 levels were positively correlated with IRS1 expression in human breast cancer.