What is CD68 a marker of?
CD68 is routinely used as a histochemical/cytochemical marker of inflammation associated with the involvement of monocytes/macrophages. 55. CD68 was also used to identify cells of macrophage lineage such as tissue histiocytes, multinucleated giant cells, Kupffer cells, and osteoclasts.
What do Kupffer cells do in the liver?
Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.
Are dendritic cells CD68 positive?
Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA (cutaneous lymphocyte-associated antigen) expression on these cells in various skin diseases. J Dermatol Sci.
Which cells are macrophages of liver?
Macrophages, the most abundant liver immune cells, play a critical role in maintaining hepatic homeostasis and the underlying mechanisms of liver diseases. Hepatic macrophages consist of resident macrophages, Kupffer cells (KCs), and monocyte-derived macrophages (MoMϕs).
What are CD68 cells?
CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).
Do all macrophages express CD68?
CD68 is predominantly expressed in late endosomes and lysosomes of macrophages, but is also found on the surface of DCs and osteoclasts (Jiang et al., 1998; Ramprasad et al., 1995).
Do human monocytes express CD68?
CD68 can be expressed by macrophage/monocytes (including Kupffer cells and microglia), basophils, dendritic cells, fibroblasts (Verh Dtsch Ges Pathol 2003;87:215, Ann Rheum Dis 2004;63:774), Langerhans cells, mast cells, myeloid cells, CD34+ progenitor cells, neutrophils, osteoclasts, activated platelets and B and T …
What are liver macrophages?
Hepatic macrophages, consisting of liver resident Kupffer cells (KCs) and monocyte-derived macrophages (MoMϕs), play a central role in maintaining homeostasis of the liver as well as contributing to the progression of acute or chronic liver injury (1).