What is ampicillin IV used for?
Ampicillin injection is used to treat certain infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and lung, blood, heart, urinary tract, and gastrointestinal tract infections. Ampicillin injection is in a class of medications called penicillins.
What should you assess before giving ampicillin?
Before using ampicillin, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
What is the pharmacology of ampicillin?
Ampicillin acts as an irreversible inhibitor of the enzyme transpeptidase, which is needed by bacteria to make the cell wall. It inhibits the third and final stage of bacterial cell wall synthesis in binary fission, which ultimately leads to cell lysis; therefore, ampicillin is usually bacteriolytic.
What is the dosage and administration of ampicillin?
Ampicillin Dosage and Administration. Ampicillin for Injection, USP, 1 g or 2 g, may also be given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injection, USP, or Bacteriostatic Water for Injection, USP, respectively, and administer slowly over at least 10 to 15 minutes.
Which is active in ampicillin sodium drug study?
Ampicillin Sodium Drug Study. A broad-spectrum semisynthetic aminopenicillin, is highly bactericidal even at low concentrations, but is inactivated by penicillinase (beta-lactamase). Active against gram-positive microorganisms such as alpha- and beta-Hemolytic streptococci, Diplococcus pneumoniae, non-penicillinase producing Staphylococci,
When to infuse ampicillin after reconstitution of the injection?
Infuse appropriate dose IV over 15—30 minutes. Direct IV injection (preparation and administration) NOTE: Direct IV injections should be administered immediately after reconstitution since the potency may decrease.
When to use bacteriostatic water for ampicillin injection?
Ampicillin for Injection, USP, 125 mg, is intended primarily for pediatric use. It also serves as a convenient dosage form when small parenteral doses of the antibiotic are required. Bacteriostatic Water for Injection, USP is not to be used as a diluent when the product will be used in newborns.