What is a seronegative arthropathy?
Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis (formerly Reiter syndrome; ReA), and undifferentiated SpA.
Is seronegative spondyloarthropathy a disability?
Objectives: Seronegative spondyloarthropathy (SpA) such as ankylosing spondylitis (AS) affects patients during their working years and may contribute to work disability (WD).
Can ankylosing spondylitis affect the brain?
While not an actual medical condition, brain fog is a symptom of chronic arthritis conditions like ankylosing spondylitis. Without getting too technical, during an AS symptom flare, signals to and from pain receptors interfere with normal brain function.
What are the different types of seronegative spondyloarthropathy?
Seronegative spondyloarthropathies are a family of joint disorders that classically include ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD) associated arthritis, reactive arthritis (formerly Reiter syndrome; ReA), and undifferentiated SpA.
What kind of disease is seronegative rheumatoid arthritis?
Seronegative rheumatoid arthritis is a type of rheumatoid arthritis in which certain antibodies are not present in the blood (most cases of RA are seropositive — when antibodies are present in the blood). Rheumatoid arthritis (RA) is an autoimmune disease, in which the body’s immune system mistakenly attacks its own tissues.
Why are seronegative spondyloarthropathies usually negative in rheumatoid factor ( RF )?
Some are strongly associated with the human leukocyte antigen B27 (HLA-B27) allele. Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies. Rheumatoid factor (RF) is usually negative in the spondyloarthropathies (hence, why they are called seronegative spondyloarthropathies).
How are seronegative spondyloarthropides related to uveitis?
Seronegative spondyloarthropathies (seronegative spondyloarthritides) share certain clinical characteristics (eg, back pain, uveitis, GI symptoms, rashes). Some are strongly associated with the HLA-B27 allele. Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies.