What is a Pseudoseptic reaction?
Abstract. Acute pseudoseptic arthritis is a very rare complication that is associated with intra-articular hyaluronic acid injections, which normally involve minimal risk. The most common adverse events that are caused by hyaluronic acid injections are inflammatory reactions or flares at the injection site.
What is the action of hyaluronic acid?
It is similar to the naturally occurring glycosaminoglycan (GAG) in joints. Hyaluronic acid works by acting as a lubricant and shock absorber, facilitating joint mobility and thereby reducing osteoarthritic pain. Hyaluronic acid has antioxidative, anti-inflammatory, and analgesic effects.
What is visco injection?
During viscosupplementation treatment for arthritis, your healthcare provider injects hyaluronic acid into your joint. This thick fluid may help reduce pain and swelling in your arthritic joint (most commonly, your knee). The bones that make up your joints usually have a cap of cartilage on their ends.
Is orthovisc cross-linked?
Our study is focused on three of the multiple-injection products available: SUPARTZ FX™ and SYNVISC® are avian-based products, whereas ORTHOVISC® is produced by bacterial fermentation. In addition, SYNVISC® is cross-linked, whereas SUPARTZ FX™ and ORTHOVISC® are not.
How long do Synvisc side effects last?
Reactions generally abate within a few days. Clinical benefit from the treatment may still occur after such reactions. The clinical trials described above included 38 patients who received a second course of SYNVISC (hylan g-f 20) injections (132 injections).
Why does my knee hurt after gel injections?
Temporary pain or swelling in the knee joint may occur after receiving hyaluronic acid injection. Call your doctor if the pain or swelling in the knee persists or becomes worse after receiving this medicine. Do not use this medicine with disinfectants containing quaternary ammonium salts (e.g., benzalkonium chloride).
What is hyaluronic acid in chemistry?
Hyaluronic acid (/ˌhaɪ. əljʊəˈrɒnɪk/; abbreviated HA; conjugate base hyaluronate), also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
Is hyaluronic acid a biologic?
Hyaluronic acid is a natural polymer biologically synthesized by cells in the body via an enzymatic process. HA production is a unique, highly controlled, and continuous process, HA is produced and secreted by cells including fibroblasts, keratinocytes, or chondrocytes.
What is gel injection?
Gel shots, or viscosupplementation, involve the injection of a gel-like fluid called hyaluronic acid (HA) into your joint to act as synovial fluid. Injecting “gel shots” to the damaged, arthritic joint can help facilitate movement and reduce pain. Pain reduction can last up to 6 months.
What is Supartz knee injection?
SUPARTZ FX is a 5-injection hyaluronic acid series that can relieve knee osteoarthritis pain for up to 6 months. Clinical studies have shown that some patients may see their osteoarthritis symptoms improve with only 3 injections of SUPARTZ FX.
Where is Orthovisc injected?
Orthovisc is injected directly into your knee joint. A healthcare provider will give you this injection. You may be given more than one injection. If so, additional injections are usually given at least 1 week after your first injection.
Who is the manufacturer of Orthovisc?
ORTHOVISC® Hyaluronan may enhance the viscoelastic properties of synovial fluid to relieve pain and increase mobility. ORTHOVISC® is manufactured by and is a registered trademark of Anika Therapeutics, Inc. All medical devices have associated risks.
Can a patient tolerate an injection after a pseudoseptic reaction?
The ability to tolerate additional injections after a pseudoseptic reaction is debatable, and some authors reported that once patients have experienced a pseudoseptic reaction, they are unable to tolerate additional injections. 44
What is the medical definition of pseudoscience?
Medical Definition of pseudoscience : a system of theories, assumptions, and methods erroneously regarded as scientific Other Words from pseudoscience
Can a Hylan injection cause a pseudoseptic reaction?
Although the sodium hyaluronates are derived naturally, hylan is chemically modified to increase its molecular weight. All three products have been shown to be well tolerated in clinical trials, however, there have been reports in the literature of pseudoseptic reactions, or severe acute inflammatory reactions, after injections with hylan.