What causes demyelinating polyneuropathy?
CIDP is caused by an abnormal immune response. CIDP occurs when the immune system attacks the myelin cover of the nerves. For this reason, CIDP is thought to be an autoimmune disease. Health care providers also consider CIDP as the chronic form of Guillain-Barré syndrome.
What does demyelinating polyneuropathy mean?
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder in which there is inflammation of nerve roots and peripheral nerves and destruction of the fatty protective covering (myelin sheath) of the nerve fibers.
What are the symptoms of CIPD?
Symptoms
- clumsiness.
- dysphagia or difficulty swallowing.
- double vision.
- foot drop.
- loss of reflexes.
- numbness in the hands or feet.
- tingling or pain in the extremities.
- unexplained fatigue.
What is mad Sam disease?
MADSAM is a multifocal asymmetric demyelinating neuropathy that causes muscle weakness and sensory loss. The disease is caused by an autoimmune response of unknown origin. MADSAM has been described in literature but the effect of pregnancy on the course of MADSAM and vice versa remains uncertain.
What causes Polyradiculopathy?
The most common cause of an acute polyradiculopathy is acute inflammatory demyelinating polyradiculopathy (also known as Guillain-Barré syndrome); however, other inflammatory, infectious, or neoplastic causes can present with similar features.
What is Lewis disease?
Lewy body dementia, also known as dementia with Lewy bodies, is the second most common type of progressive dementia after Alzheimer’s disease. Protein deposits, called Lewy bodies, develop in nerve cells in the brain regions involved in thinking, memory and movement (motor control).
How does physiotherapy help with chronic inflammatory demyelinating polyneuropathy?
Physiotherapy may improve muscle strength, function and mobility, and minimize the shrinkage of muscles and tendons and distortions of the joints. Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms.
How is Privigen used to treat chronic inflammatory demyelinating polyneuropathy?
FDA-approved indication: September 2017, immune globulin intravenous (human), 10% liquid (Privigen) was approved for the treatment of adults with chronic inflammatory demyelinating polyneuropathy (CIDP) to improve neuromuscular disability and impairment, however it was not studied for use longer than 6 months.
What are the differential diagnoses of polyneuropathy?
Differential diagnoses include chronic acquired polyneuropathies (monoclonal gammopathies, diabetes, toxic neuropathies) or inherited neuropathies (Charcot-Marie-Tooth disease or transthyretin amyloid neuropathy; see these terms). Visit the Orphanet disease page for more information.
When to use serum protein electrophoresis for polyneuropathy?
Some clinicians include serum protein electrophoresis, especially if patients have a painful sensory neuropathy not explained by diabetes. The need for other tests is determined by polyneuropathy subtype (large- or small-fiber). When EMG and clinical differentiation are inconclusive, tests for all subtypes may be necessary.