What are the symptoms of monoclonal B-cell lymphocytosis?
| Monoclonal B-cell lymphocytosis | |
|---|---|
| Symptoms | None |
| Complications | May progress to chronic lymphocytic leukemia or certain lymphoma types; increased risk of developing non-hematologic cancers, serious infections, and kidney disease |
| Duration | chronic |
| Types | CLL/SLL, atypical CLL/SLL, non-CLL/SLL, and MBL-MZ |
How often does MBL turn into CLL?
A number of biological and genetic characteristics distinguish low-count from high-count MBL. Whereas low-count MBL rarely progresses to CLL, high-count MBL progresses to CLL requiring therapy at a rate of 1% to 2% per year.
What is high count MBL?
Low count MBL does not progress to the lymphoma, known as CLL. High count MBL is when the number of abnormal lymphocytes detected in the bloodstream is more than 5000 (>0.5 x 10/9/L). High count MBL has a rare chance (around 1-2%) each year of progressing to CLL.
What is monoclonal B-cell lymphoproliferative disorder?
B-cell lymphoproliferative disorders are conditions in the blood involving uncontrolled growth of lymphocytes (white blood cells). These conditions include such cancers as multiple myeloma, Hodgkin lymphoma and chronic lymphocytic leukemia (CLL), and such precursor conditions as monoclonal B-cell lymphocytosis.
Is monoclonal B-cell lymphocytosis and autoimmune disease?
Monoclonal B-cell Lymphocytosis (MBL) is an asymptomatic condition characterized by the presence of a small (<5 × 109/l) population of clonal B cells in the peripheral blood in the absence of lymphadenopathy, cytopenias or autoimmune disease.
How do you treat MBL?
MBL is a condition that resembles CLL, but isn’t classed as leukaemia as there aren’t enough abnormal cells present. MBL doesn’t require treatment, but you will need regular blood tests to monitor your lymphocyte count. A small number of people with MBL develop CLL that requires treatment.
What is pre CLL called?
Myelodysplastic syndrome (MDS) used to be known as “pre-leukemia,” or sometimes “smoldering leukemia.” MDS is a group of blood disorders that can cause you to have low levels of: red blood cells. white blood cells.
Is monoclonal B cell lymphocytosis and autoimmune disease?
Does lymphocytosis lead to leukemia?
Monoclonal B-cell lymphocytosis (MBL) causes an increased number of one type of lymphocyte (B cells) in the blood. For a small number of people with MBL , the condition may develop into chronic lymphocytic leukemia.
What does mannose-binding lectin do?
Mannose-binding lectin plays an important role in the body’s immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system .