What are LAD2 cells?
The LAD2 mast cell line most closely resembles primary human mast cell cultures due to (1) functional FcεRI receptors and the ability to degranulate to immunologic stimuli, and (2) growth dependence on the presence of stem cell factor (SCF).
How do you find LAD2 cells?
LAD2 cells were derived from CD34+ cells following marrow aspiration of a patient with aggressive mastocytosis with no identified mutations in KIT. Another aspiration gave rise to a second cell line which has recently been re-established (LADR).
What triggers mast cells?
When triggered, these mast cells release substances that can cause signs and symptoms similar to those of an allergic reaction and, sometimes, severe inflammation that may result in organ damage. Common triggers include alcohol, spicy foods, insect stings and certain medications.
Is mastocytosis serious?
People with mastocytosis have an increased risk of developing a severe and life-threatening allergic reaction. This is known as anaphylaxis. The increased risk of anaphylaxis is caused by the abnormally high number of mast cells and their potential to release large amounts of histamine into the blood.
How long can you live with mastocytosis?
Median survival ranges from 198 months in patients with indolent systemic mastocytosis to 41 months in aggressive systemic mastocytosis and 2 months in acute mast cell leukemia.
What does a mast cell reaction feel like?
There have been many criteria, but the ones most commonly used require symptoms consistent with chronic recurrent mast cell release. These include: Recurrent abdominal pain, diarrhea, flushing, itching, nasal congestion, coughing, chest tightness, wheezing, lightheadedness, or a combination of some of these.
Is mast cell disease painful?
All these findings show that mast cells are involved in pain sensation including headache associated with neuroinflammation.