How does dengue virus enter host cells?
The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released into the cytoplasm. The virus particle comes apart, releasing the viral genome.
What does dengue do to cells?
During its journey, the dengue virus infects more cells, including those in the lymph nodes and bone marrow, macrophages in both the spleen and liver, and monocytes in the blood. The spread and increase of the virus results in viremia, a condition in which there is a high level of dengue virus in the bloodstream.
What are the parts of dengue virus?
The dengue virus has a roughly spherical structure. It is composed of the viral genome and capsid proteins surrounded by an envelope and a shell of proteins. After infecting a host cell, the dengue virus hijacks the host cell’s machinery to replicate the viral RNA genome and viral proteins.
What is the difference between dengue serotypes?
Previous reports of dengue in children have suggested that infection with secondary DENV-2 is more likely to result in severe disease compared with other serotypes. In contrast, primary DENV-1 cases were more overt whereas primary DENV-2 and DENV-3 cases were usually silent.
How dengue virus affects platelets?
When an infected mosquito bites a human, the dengue virus enters the bloodstream, it binds to platelets and replicates leading to multiplication of infectious virus. The infected platelet cells tend to destroy normal platelets which is one of the major causes for the drop in the platelet count in dengue fever.
What are the four serotypes of dengue virus?
There are four serotypes of dengue viruses, designated as DENV-1, DENV-2, DENV-3, and DENV-4; all are transmitted from human to human through the bite of certain species of Aedes mosquitoes, primarily Ae. aegypti and Ae.
Which phylum classification is the transmitter of dengue?
| Dengue virus | |
|---|---|
| Kingdom: | Orthornavirae |
| Phylum: | Kitrinoviricota |
| Class: | Flasuviricetes |
| Order: | Amarillovirales |
What is the platelet count during dengue?
A typical person has a platelet count of between 150,000 and 250,000 per microlitre of blood. About 80 to 90 per cent of patients with dengue will have levels below 100,000, while 10 to 20 per cent of patients will see critically low levels of 20,000 or less.