How do you treat Wellbutrin overdose?
Management of bupropion overdose is largely supportive Treatment with activated charcoal should be considered for patients presenting within 60 minutes of ingestion in whom the risk of aspiration is low. Whole bowel irrigation may be considered for patients with large ingestions of sustained-release preparations.
Is there an antidote for bupropion?
Treatment of an overdose of sustained release bupropion is supportive, as there is no antidote available. Gastric lavage17 and oral activated charcoal18 may be considered within an hour of overdose; but the value of further doses of charcoal or whole bowel irrigation in bupropion overdose has not been established.
What happens if you take too many bupropion?
In severe toxic doses it can cause coma, hypotension, multiple seizures, QRS widening, QTc prolongation, status epilepticus, and ventricular dysrhythmias [2]. Seizure due to intentional or unintentional overdose is among the most commonly reported toxic effect of bupropion [3–6].
How do you know if you overdose on Wellbutrin?
An overdose of bupropion can be fatal. Overdose symptoms may include muscle stiffness, hallucinations, fast or uneven heartbeat, shallow breathing, or fainting. Drinking alcohol with bupropion may increase your risk of seizures.
How much Wellbutrin is toxic?
Doubling of therapeutic dosage (as low as 600 mg) may result in seizures. The risk of seizure with therapeutic dosing (up to 450 mg/day) is 0.4%. Seizures are most common with doses > 2.5 g. Serious toxicity can be expected with doses > 6 g, and fatalities usually involve doses > 9 g.
How much Wellbutrin will cause a seizure?
Bupropion is associated with a risk of seizure at doses above 450 mg a day, especially in patients with a history of seizure or epileptic disorders. This risk appears much lower in the sustained-release bupropion preparations.
How much Wellbutrin can cause death?
The risk of seizure with therapeutic dosing (up to 450 mg/day) is 0.4%. Seizures are most common with doses > 2.5 g. Serious toxicity can be expected with doses > 6 g, and fatalities usually involve doses > 9 g.
Can bupropion be fatal?
Background: Bupropion is a unique monocyclic antidepressant that has been known to cause seizures in high therapeutic doses and in acute overdoses. Death due to ingestion, however, is a rare occurrence.
Is 600 mg of bupropion too much?
The maximum daily dose of bupropion is 450 mg, but reported cases of abuse have involved ingesting from 600 mg 8 to 1200 mg of the drug 2. Most bupropion abusers take this drug by crushing and snorting (insufflating) the pills.
What happens if you accidentally take 2 bupropion?
DO NOT take 2 doses at once. You should not take more than your prescribed dose and doing so may increase your risk of having a seizure. For bupropion XL, do not take an extra tablet to make up for the dose you forgot.
Why is Wellbutrin abused?
People who abuse drugs have tried to crush bupropion tablets and then snort or inject them in order to get a “high.” They often experience seizures instead. Wellbutrin is sometimes abused by bodybuilders and others who want to lose weight or by those who think it will enhance their sexual experiences.
What are the long term side effects of Wellbutrin?
Wellbutrin may also cause serious side effects. Some serious side effects of Wellbutrin are chest pains, irregular heartbeat, high blood pressure, disorientation, seizures, hallucinations, and difficulty swallowing or breathing.
Does Wellbutrin make you high?
Wellbutrin is one of the common drugs prisoners try to crush up and inhale to get high. It can definitely make people high, but it has that nasty little seizure side effect at the doses that would normally make someone high. That’s kind of a deterrent.
What is the lethal dose of Wellbutrin?
Even in perfect lab conditions you cannot obtain an exact lethal dose because every living creature is different. Sure you can say 10,000,000 mg of Wellbutrin is lethal but then you have to consider that 30,000mg has also been lethal in one person.