How do you reconstitute mitomycin?
Each vial of Mitosol® contains 0.2 mg of mitomycin and mannitol in a 1:2 concentration ratio. To reconstitute, add 1 mL of Sterile Water for Injection, then shake to dissolve. If product does not dissolve immediately, allow to stand at room temperature until the product dissolves into solution.
How is mitomycin instilled in the bladder?
Mitomycin is given directly into the bladder (called intravesicular), through a catheter, and left in the bladder for 1-2 hours. The dosage and schedule is determined by your healthcare provider. This drug is blue in color and may make your urine blue-green in color. This can last up to two days after each dose.
How do you mix BCG for bladder cancer?
One regimen commonly used consists of an ampul of BCG mixed with 50 mL of NaCl 0.9%, instilled once a week for six weeks and retained for two hours prior to voiding. Maintenance therapy generally consists of intravesical doses given at three-month cycles for at least two years of recurrence-free follow-up.
How do you give a mitomycin injection?
In cytostatic monochemotherapy mitomycin is usually administered intravenously as a bolus injection. The recommended dosage is 10 – 20 mg/m2 of body surface every 6 – 8 weeks, 8 – 12 mg/m2 of body surface every 3 – 4 weeks or 5-10 mg/m2 of body surface every 1-6 weeks, depending on the therapeutic scheme used.
How do you dilute Mitomycin-C?
Our preparation of the mitomycin-C includes mixing the drug with a sterile water diluent to achieve a starting concentration of 0.2 mg/ml. This is then diluted further with 2% lidocaine—the same lidocaine we would use in a retrobulbar block.
How do I dissolve MMC?
MMC is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of MMC in ethanol is approximately 0.1 mg/ml and approximately 20 mg/ml in DMSO and DMF.
What is Mitomycin instillation?
Mitomycin-C is a type of antibiotic that is only used in cancer therapy. It slows or stops the growth of cancer cells in your body. Mitomycin-C is a clear blue or purple liquid. For the therapy, we put this liquid into the bladder using a catheter (tube).
How often is Mitomycin administered?
Mitomycin comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually injected once every 6 to 8 weeks. Your doctor may need to delay your treatment or change your dose if you experience certain side effects.
How do I reconstitute my BCG vaccine?
4.1. 4 Reconstituting BCG and measles vaccines with diluent
- 1 Wash your hands and organise your equipment and work area.
- 2 Inspect the vaccine vial or ampoule.
- 3 Tap the vial or ampoule.
- 4 Open the vaccine vial.
- 5 Inspect the diluent.
- 6 Open the ampoule of diluent.
- 7 Draw diluent into the mixing syringe.
How do you reconstitute BCG?
Draw 1 ml of sterile, preservative-free saline (0.9% Sodium Chloride Injection U.S.P.) at 4– 25°C, into a small syringe (e.g., 3 ml) and add to one vial of TICE® BCG to resuspend. Gently swirl the vial until a homogenous suspension is obtained. Avoid forceful agitation which may cause clumping of the mycobacteria.
What is intravesical instillation?
Definition: Intravesical therapy involves instillation of a therapeutic agent directly into the bladder via insertion of a urethral catheter.
How often is mitomycin administered?
How often does mitomycin need to be instilled in the bladder?
The content of one vial is required for one bladder instillation. There are many intravesical mitomycin regimens, varying in dose of mitomycin used, the frequency of instillation and the duration of therapy. Unless otherwise specified, the dose of mitomycin is 40 mg mitomycin instilled into the bladder once weekly.
Is it safe to take mitomycin intravenously?
Mitomycin should be given intravenously only, using care to avoid extravasation of the compound. If extravasation occurs, cellulitis, ulceration, and slough may result. Each vial contains either mitomycin 5 mg and mannitol 10 mg, or mitomycin 20 mg and mannitol 40 mg, or mitomycin 40 mg and mannitol 80 mg.
What is the plasma level of mitomycin after instillation?
Absorption Following intravesical administration only a small proportion of mitomycin reaches the serum. Maximum peak plasma levels of 0.05 µg/ml 40 minutes after intravesical instillation of 40 mg mitomycin have been measured. This is well below the level of 0.4 µg/ml of mitomycin in serum which is known to be myelosuppressive.
How long does it take mitomycin to clear the serum?
In humans, mitomycin is rapidly cleared from the serum after intravenous administration. Time required to reduce the serum concentration by 50% after a 30 mg bolus injection is 17 minutes. After injection of 30 mg, 20 mg, or 10 mg IV, the maximal serum concentrations were 2.4 mcg/mL, 1.7 mcg/mL, and 0.52 mcg/mL, respectively.