What is the RTS,S vaccine?
RTS,S/AS01 (RTS,S) is the world’s first malaria vaccine shown to provide partial protection against malaria in young children. The vaccine is being provided to young children through national immunization programs in parts of three sub-Saharan African countries as part of a pilot introduction that began in 2019.
What does RTS,S stand for?
RTS,S is a scientific name given to this malaria vaccine candidate and represents its composition. The ‘R’ stands for the central repeat region of Plasmodium (P.) falciparum circumsporozoite protein (CSP); the ‘T’ for the T-cell epitopes of the CSP; and the ‘S’ for hepatitis B surface antigen (HBsAg).
Who makes RTS,S malaria vaccine?
The RTS,S/AS01e malaria vaccine, was developed by GSK for more than 30 years. The RTS,S vaccine was created in 1987 as part of a collaboration between GlaxoSmithKline and the Walter Reed Army Institute of Research that began in 1984.
How is the RTS,S vaccine administered?
RTS,S/AS01 is delivered as a lyophilized injection delivered intramuscularly. Four doses are currently indicated for children, with the first dose given at 5 months of age. The first 3 doses are administered monthly, and the third should be completed by 9 months of age.
How long has RTS,S vaccine been in development?
The RTS,S malaria vaccine is the result of 30 years of research and development by GSK and through a partnership with PATH, with support from a network of African research centres. The Bill & Melinda Gates Foundation provided catalytic funding for late-stage development of RTS,S between 2001 and 2015.
How effective is the RTS,S malaria vaccine?
It was shown that RTS,S/AS02D had a vaccine efficacy of 65.9%. These results indicated that development of an effective vaccine against malaria was feasible.
How effective is RTS,S malaria vaccine?
How long has RTS S vaccine been in development?
Who developed RTS,S?
The RTS,S vaccine was conceived of and created in the late 1980s by scientists working at SmithKline Beecham Biologicals (now GlaxoSmithKline (GSK) Vaccines) laboratories in Belgium….RTS,S.
| Vaccine description | |
|---|---|
| Routes of administration | intramuscular injection (0.5 mL) |
| Legal status | |
| Legal status | In general: ℞ (Prescription only) |
Why does the US not have malaria?
Malaria transmission in the United States was eliminated in the early 1950s through the use of insecticides, drainage ditches and the incredible power of window screens. But the mosquito-borne disease has staged a comeback in American hospitals as travelers return from parts of the world where malaria runs rampant.
What is the first malaria vaccine?
RTS,S/ASO1 (RTS. S), trade name Mosquirix, which was endorsed by the World Health Organisation (WHO) on Wednesday (October 6), is the first and, to date only, vaccine shown to have the capability of significantly reducing malaria, and life-threatening severe malaria, in tests on young African children.