What is the Jod Basedow phenomenon?
Jod-Basedow phenomenon occurs due to either overactivation of the entire thyroid gland or, more commonly, autonomous nodules within the gland after iodine repletion without adequate feedback control from the pituitary gland. This escape from the protective Wolff-Chaikoff effect is called the Jod-Basedow phenomenon.
Can amiodarone cause hypothyroidism?
Amiodarone can lead to both hypothyroidism (amiodarone-induced hypothyroidism) and less commonly hyperthyroidism (amiodarone-induced thyrotoxicosis) and relates to high iodine content within the molecule as well as to several unique intrinsic properties of amiodarone.
What are the symptoms of low T3 and T4?
When you have too little T3 or T4, you might experience:
- Weight gain.
- Memory issues.
- Lethargy.
- Fatigue.
- Constipation.
- Brain fog.
- Dry skin.
Is Basedow disease curable?
Symptoms of Basedow’s disease can be wide-ranging, including anxiety, diarrhea, and skin abnormalities. However, there are safe and effective treatment options that help most people with this condition live long, full lives.
Does Graves disease cause clubbing?
Thyroid acropachy is rare and occurs in less than 1% of patients with Graves’ disease. Thyroid acropachy consists of clubbing of the digits, swelling of the hands and feet, and periosteal proliferation of the distal long bones.
What causes Wolff Chaikoff effect?
Iodine Deficiency and Iodine Excess Hypothyroidism can be caused by iodine deficiency (see Chapter 88) or iodine excess. Inorganic iodide in excess of daily doses of 500 to 1000 mcg inhibits organification of iodide, known as the Wolff-Chaikoff effect.
What does amiodarone do to thyroid?
However, amiodarone is associated with a number of side effects, including thyroid dysfunction (both hypo- and hyperthyroidism), which is due to amiodarone’s high iodine content and its direct toxic effect on the thyroid.
Does amiodarone affect TSH levels?
Amiodarone induces alterations in thyroid hormone levels by actions on thyroidal secretion, on the peripheral tissues, and probably also on the pituitary gland. These actions result in elevations in serum T4 and rT3 concentrations, transient increases in TSH concentrations, and decreases in T3 concentrations.
Will I gain weight after treating hyperthyroidism?
Treatment of hyperthyroidism commonly results in weight gain, but the extent of weight gain is not well known. Patients may regain the weight they had lost or may overshoot and become obese.