What is the advantage of cystatin C over 24 hour urine creatinine clearance for monitoring GFR?
As GFR decreased from 120 to 20 mL/min/1.73 m2, cystatin C increased more significantly that serum creatinine, giving a stronger signal in comparison to that of creatinine over the range of the measured GFR.
How is Cystatin C clearance calculated?
(iv) GFR calculated according to CKD-EPI creatinine and cystatin formula: 177.6 × ( serum creatinine ( mg dL ) ) − 0.65 × ( serum cystatin C ( mg L ) ) − 0.57 × age − 0.2 . The correction factor of 0.82 was used for women.
How is Cystatin C excreted?
Metabolism and Excretion After filtration, approximately 99% of the filtered cystatin C is reabsorbed and catabolized by the proximal tubular cells. There is some evidence for the existence of tubular secretion as well as extrarenal elimination, which has been estimated at 15% to 21% of renal clearance.
What is a healthy creatinine clearance?
Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (1.496 to 2.18 mL/s).
What does high cystatin C indicate?
If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well. A blood test for cystatin C can help your healthcare provider find your GFR (glomerular filtration rate).
What is the normal glomerular filtration rate?
A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.
What does cystatin C measure?
This test measures the amount of a protein called cystatin C in your blood. Your body makes cystatin C constantly, and the protein is found in different fluids, including blood, spinal fluid, and breast milk. When your kidneys are healthy, they filter cystatin C out of the blood so it can be excreted in your urine.
Does dehydration affect creatinine clearance?
Dehydration generally causes BUN levels to rise more than creatinine levels. This causes a high BUN-to-creatinine ratio. Kidney disease or blocked urine flow from your kidney causes both BUN and creatinine levels to rise.