What is the A1298C mutation?
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10, 111-113, doi:10.1038/ng0595-111 (1995). 2. Chango, A. et al.
Is Metafolin methylated folate?
Methyl Folate supplies 1,000 mcg of biologically active folate per tablet from Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF). 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health.
Is Metafolin synthetic?
Metafolin®, L-5-methyltetrahydrofolate (L-5-MTHF) is synthetic.
What is heterozygous A1298C?
Being homozygous for MTHFR A1298C leads to 60% of normal enzyme function. People may also have 1 abnormal MTHFR C677T gene plus 1 abnormal MTHFR A1298C gene; this is termed double heterozygous. Decreased enzyme function may also result.
What happens if you have a mutation in MTHFR A1298C?
If you have a mutation in your MTHFR A1298C gene, your body is impacted very differently from a mutation at MTHFR C677T or MTHFR 03. Most people mean MTHFR C677T when they refer to MTHFR, because it is a common mutation and it has a major impact. But MTHFR A1298C is significant also.
What is the difference between MTHFR c1298c and C677T?
MTHFR C1298C = homozygous mutation (two mutations) MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation One of the biggest concerns for those with an MTHFR mutation is the effect it may have on homocysteine levels in the blood.
Is there any information on the A1298C mutation?
There is little known about the A1298C MTHFR mutation. Or so it seems. Research seems to ignore it almost completely while the C677T MTHFR mutation gets all the attention and glory. For those who have the A1298C MTHFR mutation, this is frustrating.
What happens to methionine in MTHFR 03?
MTHFR 03 generates the more profound slowdown of the two. As a result of either of these mutations, you produce less 5-methylfolate to convert homocysteine back into methionine, and as a result you produce fewer methyl groups. I have a downloadable, no-cost ebook available here that explains this process in Chapter 3.