What is Citrasate?
About Citrasate® Liquid Acid Concentrate Citrasate® contains citric acid, which forms citrate in solution, is easily metabolized in the body, and has a long and safe history of use in medicine, most notably as an anticoagulant used in the collection and storage of blood for transfusion.
What is Bibag?
Device Description. The Fresenius 2008T Hemodialysis Machine with bibag System is indicated for use in bicarbonate hemodialysis for acute and chronic renal failure. The bibag is a specialized, single-use, sealed bag filled with USP grade dry sodium bicarbonate powder.
What is Naturalyte?
Granuflo and Naturalyte are two substances manufactured and marketed by Fresenius Medical Care for use in dialysis treatments for acute and chronic kidney failure. Both concentrates have been linked to an increased risk of heart attacks and other health complications, sometimes resulting in death.
What is acid concentrate in dialysis?
Acid concentrate contains acetic acid, citric acid or sodium diacetate to maintain the final dialysate pH. Organic acids from the acid concentrate consume bicarbonate from the bicarbonate concentrate, leading to an equivalent gain of sodium acetate in the final dialysate solution.
Why is Bicarb used in dialysis?
Abstract. Chronic metabolic acidosis is common in dialysis patients. Bicarbonate administration via the dialysate helps maintain the acid–base balance in these patients.
What is GranuFlo used for?
GranuFlo, a dialysis product manufactured by Fresenius, is used to clean the blood of patients undergoing hemodialysis for treatment of renal (kidney) failure. It is estimated that GranuFlo is used by more than a third of the 400,000 hemodialysis patients located in over 5,700 dialysis centers across the United States.
What is Dialysing fluid?
Dialysate, also called dialysis fluid, dialysis solution or bath, is a solution of pure water, electrolytes and salts, such as bicarbonate and sodium. The purpose of dialysate is to pull toxins from the blood into the dialysate. The way this works is through a process called diffusion.
What type of solution is used in dialysis?
How do you mix bicarbonate of dialysis?
Acidic concentrate for preparation of a ready-to-use bicarbonate haemodialysis solution in mixture 1+34 or 1+44. To manufacture the ready-to-use dialysis fluid, the acidic bicarbonate haemodialysis concentrates are mixed by the dialysis machine. The standard dilution ratio is 1+34 or 1+44.
Where is bicarbonate synthesized?
proximal convoluted tubule
a) In the proximal convoluted tubule (PCT) cell, carbonic anhydrase (not shown) generates bicarbonate and hydrogen from water and carbon dioxide. Sodium in filtered urine is resorbed in exchange (with a sodium/hydrogen cotransporter) for the hydrogen produced from carbonic anhydrase.
What can citrasate liquid acid concentrate be used for?
Access the latest innovations in dialysate, including citric-based acid concentrates. Citrasate ® contains citric acid, which forms citrate in solution, is easily metabolized in the body, and has a long and safe history of use in medicine, most notably as an anticoagulant used in the collection and storage of blood for transfusion.
How is citrasate used in bicarbonate dialysis?
Citrasate, a new acid concentrate for bicarbonate dialysis, is unique because it uses citric acid rather than acetic acid for acidification. Citrate is a well known anticoagulant that functions by binding serum calcium thereby reducing the calcium available to participate in the blood’s clotting cascade.
Who is the owner of the name citrasate?
Citrasate is a registered trademark of Advanced Renal Technologies, Inc. in the United States and is used under license. All other trademarks are the property of their respective owners. P/N 101345-01 Rev D 11/2019
Why is citrate dialysate used for blood clotting?
Rationale/Background: Citrate dialysate contains citric acid – a physiological acid that the body can quickly metabolize and which also has anticoagulation properties. The anticoagulation mechanism of citrate dialysate occurs because citrate binds to calcium (ionized or “free” calcium), thus removing calcium from the blood clotting cascade.