What is chromosome 6p deletion?
Chromosome 6p deletion is a chromosome abnormality that occurs when there is a missing copy of the genetic material located on the short arm (p) of chromosome 6. The severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved.
Which chromosome is responsible for pain?
COMT inhibition showed increased pain sensitivity to hyperalgesia (increased sensitivity to pain) and allodynia (non-painful stimuli that causes pain). The COMT gene is on the long arm of chromosome 22 at 22q11.
What does the sixth chromosome do?
Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the Major Histocompatibility Complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.
What genes are located on chromosome 6?
Which part of the body does not feel pain?
The brain itself does not feel pain because there are no nociceptors located in brain tissue itself. This feature explains why neurosurgeons can operate on brain tissue without causing a patient discomfort, and, in some cases, can even perform surgery while the patient is awake.
What is the disease where you can’t feel pain?
Congenital insensitivity to pain is a rare disorder, first described in 1932 by Dearborn as Congenital pure analgesia. Congenital insensitivity to pain and anhydrosis (CIPA) is a very rare and extremely dangerous condition. People with CIPA cannot feel pain [1].
What is the function of chromosome 6?
What are the symptoms of chromosome 6p deletion?
The severity of the condition and the signs and symptoms depend on the size and location of the deletion and which genes are involved. Features that often occur in people with chromosome 6p deletion include developmental delay, intellectual disability, behavioral problems, and distinctive facial features.
Where is the missing chromosome on chromosome 6?
Chromosome 6p deletion is a chromosome abnormality that occurs when there is a missing copy of the genetic material located on the short arm (p) of chromosome 6.
What happens when the p arm of chromosome 5 is deleted?
The cry-do-cat syndrome is a type of structural aberration in which some portion of the “p” arm of the chromosome 5 deleted. Similarly, 6p deletion is such a type of structural aberration that causes several congenital problems which are very rare throughout the world.
How big is the p arm of chromosome 6?
The total size of chromosome 6 is 170Mb in which the short “p” arm and longer “q” arm contains a 60Mb portion and a 110Mb portion of the total size, respectively. Chromosome 6 is involved in some of the well-known diseases such as maple syrup urine disease, Parkinson’s disease, polycystic kidney disease and Rheumatoid arthritis.